ppt_2 protein (Legionella steigerwaltii) - STRING interaction network

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Score

ppt_2

Hypoxanthine-guanine phosphoribosyltransferase. (186 aa)

Predicted Functional Partners:

xapA

0.973

guaA

0.922

gmk

0.915

purH

0.906

ppt_1

0.899

purA

0.898

surE

0.890

yfiH

0.882

guaB

0.880

guaC

0.880

Your Current Organism:

Legionella steigerwaltii

NCBI taxonomy Id: 460
Other names: ATCC 35302, CCUG 29674, CCUG 56441, CIP 103851, DSM 23076, JCM 7558, L. steigerwaltii, NCTC 11991, strain SC-18-C9

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
gmk	guaA	Lstg_0953	Lstg_0295	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.991
gmk	guaB	Lstg_0953	Lstg_0294	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.692
gmk	guaC	Lstg_0953	Lstg_2195	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Guanosine monophosphate reductase GuaC.	0.690
gmk	ppt_1	Lstg_0953	Lstg_0016	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine-guanine phosphoribosyltransferase.	0.916
gmk	ppt_2	Lstg_0953	Lstg_2115	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypoxanthine-guanine phosphoribosyltransferase.	0.915
gmk	purA	Lstg_0953	Lstg_1690	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.401
gmk	surE	Lstg_0953	Lstg_0169	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.870
guaA	gmk	Lstg_0295	Lstg_0953	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.991
guaA	guaB	Lstg_0295	Lstg_0294	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.999
guaA	guaC	Lstg_0295	Lstg_2195	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Guanosine monophosphate reductase GuaC.	0.998
guaA	ppt_1	Lstg_0295	Lstg_0016	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Hypoxanthine-guanine phosphoribosyltransferase.	0.922
guaA	ppt_2	Lstg_0295	Lstg_2115	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Hypoxanthine-guanine phosphoribosyltransferase.	0.922
guaA	purA	Lstg_0295	Lstg_1690	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.947
guaA	purH	Lstg_0295	Lstg_1664	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase (bifunctional).	0.961
guaA	surE	Lstg_0295	Lstg_0169	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.959
guaA	xapA	Lstg_0295	Lstg_1976	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.579
guaB	gmk	Lstg_0294	Lstg_0953	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.692
guaB	guaA	Lstg_0294	Lstg_0295	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.999
guaB	guaC	Lstg_0294	Lstg_2195	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	Guanosine monophosphate reductase GuaC.	0.894
guaB	ppt_1	Lstg_0294	Lstg_0016	IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	Hypoxanthine-guanine phosphoribosyltransferase.	0.880