gbsA protein (Legionella steigerwaltii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

gbsA

Glycine betaine aldehyde dehydrogenase. (475 aa)

Predicted Functional Partners:

Lstg_1863

0.915

Hgd

0.854

acsB

0.852

mmsA

0.850

nylA

0.837

pdc

0.825

panC

0.808

putA

0.768

pta

0.748

hmp

0.708

Your Current Organism:

Legionella steigerwaltii

NCBI taxonomy Id: 460
Other names: ATCC 35302, CCUG 29674, CCUG 56441, CIP 103851, DSM 23076, JCM 7558, L. steigerwaltii, NCTC 11991, strain SC-18-C9

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hgd	Lstg_1863	Lstg_0850	Lstg_1863	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	acyl-CoA synthetase.	0.495
Hgd	acsB	Lstg_0850	Lstg_0849	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.978
Hgd	gbsA	Lstg_0850	Lstg_2932	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Glycine betaine aldehyde dehydrogenase.	0.854
Hgd	mmsA	Lstg_0850	Lstg_0851	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.990
Hgd	pta	Lstg_0850	Lstg_0614	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Phosphate acetyl/butaryl transferase.	0.880
Lstg_1863	Hgd	Lstg_1863	Lstg_0850	acyl-CoA synthetase.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.495
Lstg_1863	acsB	Lstg_1863	Lstg_0849	acyl-CoA synthetase.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.950
Lstg_1863	gbsA	Lstg_1863	Lstg_2932	acyl-CoA synthetase.	Glycine betaine aldehyde dehydrogenase.	0.915
Lstg_1863	hmp	Lstg_1863	Lstg_3025	acyl-CoA synthetase.	Oxidoreductase, FAD-binding protein.	0.997
Lstg_1863	mmsA	Lstg_1863	Lstg_0851	acyl-CoA synthetase.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.915
Lstg_1863	nylA	Lstg_1863	Lstg_2066	acyl-CoA synthetase.	Amidase; Belongs to the amidase family.	0.552
Lstg_1863	pdc	Lstg_1863	Lstg_2707	acyl-CoA synthetase.	Pyruvate decarboxylase.	0.566
Lstg_1863	pta	Lstg_1863	Lstg_0614	acyl-CoA synthetase.	Phosphate acetyl/butaryl transferase.	0.976
Lstg_1863	putA	Lstg_1863	Lstg_2045	acyl-CoA synthetase.	Bifunctional PutA protein (proline dehydrogenase/ delta-1-pyrroline-5-carboxylate dehydrogenase); Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.	0.726
acsB	Hgd	Lstg_0849	Lstg_0850	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.978
acsB	Lstg_1863	Lstg_0849	Lstg_1863	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	acyl-CoA synthetase.	0.950
acsB	gbsA	Lstg_0849	Lstg_2932	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Glycine betaine aldehyde dehydrogenase.	0.852
acsB	hmp	Lstg_0849	Lstg_3025	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Oxidoreductase, FAD-binding protein.	0.709
acsB	mmsA	Lstg_0849	Lstg_0851	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.965
acsB	pta	Lstg_0849	Lstg_0614	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Phosphate acetyl/butaryl transferase.	0.978