Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Score
Mnod_0033(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (737 aa)    
Predicted Functional Partners:
Mnod_1516
PFAM: Ppx/GppA phosphatase; KEGG: met:M446_0659 Ppx/GppA phosphatase.
 
 
 0.941
Mnod_5542
PFAM: Ppx/GppA phosphatase; KEGG: met:M446_5159 Ppx/GppA phosphatase.
 
 
 0.941
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.930
Mnod_6550
TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: met:M446_5947 MazG family protein.
  
 
 0.926
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.917
Mnod_2387
Adenylate/guanylate cyclase with integral membrane sensor; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; histidine kinase HAMP region domain protein; KEGG: met:M446_6425 adenylate/guanylate cyclase with integral membrane sensor.
    
 0.908
Mnod_0315
PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: met:M446_2293 adenylate/guanylate cyclase.
     
 0.904
Mnod_6038
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
   
 
  0.903
Mnod_0089
PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; TPR repeat-containing protein; SMART: Tetratricopeptide domain protein; KEGG: met:M446_0534 adenylate/guanylate cyclase.
   
 
  0.900
Mnod_0096
PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: met:M446_0534 adenylate/guanylate cyclase.
   
 
  0.900
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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