STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Mnod_0555KEGG: mrd:Mrad2831_6255 DNA-directed DNA polymerase. (94 aa)    
Predicted Functional Partners:
Mnod_0559
PFAM: peptidase S24 and S26 domain protein; KEGG: mpo:Mpop_0340 peptidase S24 and S26 domain protein; Belongs to the peptidase S24 family.
 
 
 0.885
Mnod_3941
PFAM: peptidase S24 and S26 domain protein; KEGG: mpo:Mpop_0340 peptidase S24 and S26 domain protein; Belongs to the peptidase S24 family.
 
 
 0.860
Mnod_4997
PFAM: peptidase S24 and S26 domain protein; KEGG: mpo:Mpop_0340 peptidase S24 and S26 domain protein; Belongs to the peptidase S24 family.
 
 
 0.860
Mnod_7045
PFAM: peptidase S24 and S26 domain protein; KEGG: mpo:Mpop_0340 peptidase S24 and S26 domain protein; Belongs to the peptidase S24 family.
 
 
 0.860
Mnod_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.802
Mnod_7600
KEGG: mpo:Mpop_2589 hypothetical protein.
   
 0.802
Mnod_5155
KEGG: met:M446_4498 hypothetical protein.
  
  
 0.775
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.669
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.619
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
 
 
 0.551
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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