STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Mnod_1052PFAM: PemK family protein; KEGG: swi:Swit_3386 transcriptional modulator of MazE/toxin, MazF. (119 aa)    
Predicted Functional Partners:
Mnod_1051
KEGG: swi:Swit_3387 hypothetical protein.
 
   
 0.965
Mnod_7064
KEGG: met:M446_6241 hypothetical protein.
 
 
 
 0.543
Mnod_2221
Transcriptional regulator, HxlR family; PFAM: regulatory protein MarR; helix-turn-helix HxlR type; KEGG: mrd:Mrad2831_5865 HxlR family transcriptional regulator.
   
    0.505
Mnod_2385
PFAM: helix-turn-helix HxlR type; KEGG: bja:bll5105 transcriptional regulatory protein.
   
    0.505
Mnod_3139
PFAM: helix-turn-helix HxlR type; KEGG: xau:Xaut_1278 HxlR family transcriptional regulator.
   
    0.505
Mnod_6638
PFAM: helix-turn-helix HxlR type; KEGG: mrd:Mrad2831_1367 HxlR family transcriptional regulator.
   
    0.505
Mnod_7474
PFAM: helix-turn-helix HxlR type; KEGG: mms:mma_2400 transcriptional regulator.
   
    0.505
nnrD
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
       0.492
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.486
Mnod_6211
TIGRFAM: addiction module antidote protein, CC2985 family; PFAM: protein of unknown function UPF0156; KEGG: sus:Acid_3821 CopG/Arc/MetJ family transcriptional regulator.
   
 
 0.471
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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