Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (453 aa)    
Predicted Functional Partners:
Mnod_1191
TIGRFAM: maleylacetoacetate isomerase; PFAM: Glutathione S-transferase domain; KEGG: mpo:Mpop_1046 maleylacetoacetate isomerase.
 
 
 0.998
Mnod_1192
TIGRFAM: fumarylacetoacetase; PFAM: fumarylacetoacetate (FAA) hydrolase; Domain of unknown function DUF1969; KEGG: met:M446_2533 fumarylacetoacetase.
 
  
 0.995
Mnod_0122
PFAM: Xylose isomerase domain protein TIM barrel; KEGG: met:M446_4755 4-hydroxyphenylpyruvate dioxygenase.
 
 0.956
Mnod_1196
PFAM: monooxygenase FAD-binding; FAD dependent oxidoreductase; KEGG: rso:RS01747 hypothetical protein.
 
  
 0.836
Mnod_3689
PFAM: protein of unknown function DUF1446; KEGG: mrd:Mrad2831_4048 hypothetical protein.
  
 
 0.816
Mnod_2854
KEGG: met:M446_2715 fumarylacetoacetate hydrolase family protein.
 
  
 0.768
Mnod_1195
KEGG: rpe:RPE_0910 hypothetical protein.
 
     0.764
Mnod_1197
PFAM: beta-lactamase domain protein; KEGG: bte:BTH_I1394 metallo-beta-lactamase family protein.
 
    0.763
Mnod_5972
PFAM: transcriptional coactivator/pterin dehydratase; KEGG: met:M446_5747 transcriptional coactivator/pterin dehydratase.
  
  
 0.728
Mnod_1198
PFAM: regulatory protein MarR; KEGG: xau:Xaut_1301 MarR family transcriptional regulator.
 
     0.721
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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