Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Mnod_1312PFAM: SWIB/MDM2 domain protein; KEGG: met:M446_0926 SWIB/MDM2 domain-containing protein. (110 aa)    
Predicted Functional Partners:
Mnod_5352
KEGG: met:M446_5045 putative DNA topoisomerase I.
    
 
 0.717
Mnod_2267
Hypothetical protein; KEGG: mes:Meso_1199 helicase-like.
  
 
 0.619
Mnod_3693
PFAM: helicase domain protein; SMART: DEAD-like helicases; KEGG: met:M446_1272 type III restriction protein res subunit.
    
 0.563
parE
DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
    
 
 0.524
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.524
Mnod_1313
PFAM: aldo/keto reductase; KEGG: met:M446_0927 aldo/keto reductase.
  
    0.515
Mnod_1390
SMART: WD-40 repeat protein; KEGG: met:M446_0862 WD-40 repeat-containing protein.
    
  0.441
Mnod_5293
PFAM: WD-40 repeat protein; cytochrome c class I; KEGG: met:M446_3100 cytochrome c class I.
    
  0.441
Mnod_2090
PFAM: Ankyrin; KEGG: met:M446_4648 ankyrin.
    
   0.417
Mnod_2960
Hypothetical protein.
    
   0.417
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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