Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Mnod_1341PFAM: phospholipase D/Transphosphatidylase; KEGG: met:M446_0903 phospholipase D/transphosphatidylase. (474 aa)    
Predicted Functional Partners:
Mnod_1343
PFAM: Endonuclease/exonuclease/phosphatase; KEGG: met:M446_0900 endonuclease/exonuclease/phosphatase.
 
  
 0.658
ispDF
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
     
 0.539
psd
Phosphatidylserine decarboxylase related protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
   
 
 0.459
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.458
Mnod_2351
KEGG: met:M446_2987 hypothetical protein.
  
     0.451
Mnod_5352
KEGG: met:M446_5045 putative DNA topoisomerase I.
  
    0.448
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 0.444
Mnod_0141
TIGRFAM: GNAT-family acetyltransferase TIGR03103; PFAM: phosphoribosylglycinamide synthetase; GCN5-related N-acetyltransferase; RimK domain protein ATP-grasp; KEGG: met:M446_2679 GNAT family acetyltransferase.
 
   
 0.439
Mnod_0636
KEGG: cyt:cce_5237 hypothetical protein.
    
 0.439
Mnod_1062
PFAM: ribonuclease BN; KEGG: met:M446_1426 ribonuclease BN.
 
  
 0.432
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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