Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Mnod_1474PFAM: DNA methylase N-4/N-6 domain protein; KEGG: met:M446_0710 DNA methylase N-4/N-6 domain-containing protein; Belongs to the N(4)/N(6)-methyltransferase family. (368 aa)    
Predicted Functional Partners:
lexA
SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
 0.794
Mnod_4709
PFAM: GcrA cell cycle regulator; KEGG: met:M446_4194 GcrA cell cycle regulator.
  
   
 0.704
Mnod_7422
PFAM: GcrA cell cycle regulator; KEGG: met:M446_6684 GcrA cell cycle regulator.
  
   
 0.704
Mnod_6286
Putative two component transcriptional regulator, winged helix family; PFAM: transcriptional regulator domain protein; KEGG: gox:GOX1693 cell cycle transcriptional regulator CtrA.
  
   
 0.599
Mnod_6738
KEGG: met:M446_6497 cobalt chelatase, pCobT subunit; TIGRFAM: cobalt chelatase, pCobT subunit; PFAM: Cobalt chelatase CobT subunit; SMART: von Willebrand factor type A.
 
     0.563
Mnod_6741
PFAM: heat shock protein DnaJ domain protein; KEGG: met:M446_6495 heat shock protein DnaJ domain-containing protein.
  
 
   0.562
Mnod_4555
PFAM: HNH endonuclease; SMART: HNH nuclease; KEGG: met:M446_3060 HNH endonuclease.
 
  
 0.560
Mnod_0693
KEGG: met:M446_1097 hypothetical protein.
  
     0.543
parE
DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
 
   
 0.497
Mnod_6740
TIGRFAM: cobalt chelatase, pCobS small subunit; PFAM: ATPase associated with various cellular activities AAA_5; KEGG: met:M446_6496 cobalt chelatase, pCobS small subunit.
 
    0.496
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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