Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
Mnod_1597KEGG: mes:Meso_2483 putative Sir2-like transcriptional silencer protein. (286 aa)    
Predicted Functional Partners:
Mnod_4764
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
   
   0.765
Mnod_0441
PFAM: LmbE family protein; KEGG: met:M446_2069 LmbE family protein.
  
     0.701
Mnod_3693
PFAM: helicase domain protein; SMART: DEAD-like helicases; KEGG: met:M446_1272 type III restriction protein res subunit.
 
     0.662
Mnod_0220
HAD-superfamily hydrolase, subfamily IIB; Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
   
    0.604
nhaA
Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
   
    0.604
Mnod_0959
KEGG: met:M446_1671 nucleotidyl transferase.
  
     0.601
Mnod_0434
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: met:M446_2076 radical SAM domain-containing protein.
  
     0.592
Mnod_0961
KEGG: met:M446_1673 glycosyl transferase, group 1.
  
     0.490
Mnod_0134
KEGG: met:M446_2673 hypothetical protein.
  
     0.439
Mnod_1598
PFAM: Citrate transporter; TrkA-C domain protein; KEGG: met:M446_0502 TrkA domain-containing protein.
       0.425
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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