Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Mnod_1817TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter; KEGG: met:M446_5498 ammonium transporter. (500 aa)    
Predicted Functional Partners:
Mnod_1818
PFAM: nitrogen regulatory protein P-II; KEGG: met:M446_5499 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.995
Mnod_7409
PFAM: nitrogen regulatory protein P-II; KEGG: met:M446_6587 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 0.989
Mnod_1170
PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: met:M446_1812 glutamate synthase (ferredoxin).
 
  
 0.849
Mnod_6538
Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: met:M446_5929 signal transduction histidine kinase, nitrogen specific, NtrB.
  
 
 0.817
Mnod_6212
KEGG: mpo:Mpop_4776 PAS/PAC sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.
  
 
 0.782
nifH
Nitrogenase iron protein; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
  
  
 0.744
ureB
TIGRFAM: urease, beta subunit; urease, gamma subunit; PFAM: Urease beta subunit; Urease gamma subunit region; KEGG: met:M446_2213 urease, gamma subunit; Belongs to the urease beta subunit family.
  
  
 0.726
Mnod_4507
PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: met:M446_4572 glutamate--ammonia ligase.
  
  
 0.651
glnD
UTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism.
 
   
 0.629
Mnod_3383
TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: bja:blr4835 glutamine synthetase I.
  
  
 0.617
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
Server load: low (22%) [HD]