Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Mnod_2084PFAM: fumarate lyase; KEGG: met:M446_4654 fumarate lyase. (451 aa)    
Predicted Functional Partners:
Mnod_2083
TIGRFAM: 3-oxoadipate enol-lactonase; PFAM: alpha/beta hydrolase fold; Carboxymuconolactone decarboxylase; KEGG: met:M446_4655 3-oxoadipate enol-lactonase.
 
 
 0.991
Mnod_2087
TIGRFAM: protocatechuate 3,4-dioxygenase, beta subunit; PFAM: intradiol ring-cleavage dioxygenase; KEGG: met:M446_4651 protocatechuate 3,4-dioxygenase, beta subunit.
 
 
 0.987
Mnod_2086
TIGRFAM: protocatechuate 3,4-dioxygenase, alpha subunit; PFAM: intradiol ring-cleavage dioxygenase; KEGG: met:M446_4652 protocatechuate 3,4-dioxygenase, alpha subunit.
 
 
 0.985
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.948
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 
 0.948
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.947
purM
TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: met:M446_5164 phosphoribosylformylglycinamidine cyclo-ligase.
  
 
 0.946
purD
TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; KEGG: met:M446_6062 phosphoribosylamine--glycine ligase; Belongs to the GARS family.
  
 
 0.943
purC
TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: mex:Mext_0587 phosphoribosylaminoimidazole-succinocarboxamide synthase.
 
 0.942
purC-2
PFAM: SAICAR synthetase; KEGG: met:M446_3647 phosphoribosylaminoimidazolesuccinocarboxamide synthase.
  
 
 0.933
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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