Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Mnod_2186PFAM: protein of unknown function DUF815; KEGG: met:M446_2488 hypothetical protein. (295 aa)    
Predicted Functional Partners:
secD
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
 
     0.619
yajC
Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
  
    0.618
Mnod_2190
PFAM: protein of unknown function DUF498; KEGG: met:M446_2493 hypothetical protein.
 
     0.596
Mnod_5818
PFAM: Prephenate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: met:M446_5258 prephenate dehydrogenase.
 
     0.585
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
   0.545
secF
Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
       0.487
Mnod_2191
PFAM: Squalene/phytoene synthase; KEGG: met:M446_2494 squalene/phytoene synthase.
       0.484
Mnod_4432
PFAM: phospholipid/glycerol acyltransferase; KEGG: met:M446_3391 phospholipid/glycerol acyltransferase.
 
    0.431
Mnod_7271
PFAM: regulatory protein MarR; KEGG: met:M446_6016 MarR family transcriptional regulator.
  
     0.423
Mnod_5446
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; acetolactate synthase small subunit; KEGG: met:M446_0238 acetolactate synthase, small subunit.
 
     0.416
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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