Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
Mnod_3112PFAM: UspA domain protein; sodium/hydrogen exchanger; KEGG: met:M446_2825 sodium/hydrogen exchanger. (748 aa)    
Predicted Functional Partners:
Mnod_4976
TIGRFAM: potassium efflux system protein; PFAM: TrkA-N domain protein; sodium/hydrogen exchanger; KEGG: met:M446_4947 potassium efflux system protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
 
  
0.736
Mnod_7573
PFAM: TrkA-N domain protein; TrkA-C domain protein; KEGG: pol:Bpro_0214 TrkA-N.
  
  
 0.591
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.585
Mnod_7391
PFAM: sodium/hydrogen exchanger; KEGG: met:M446_6647 sodium/hydrogen exchanger.
   
 
 0.581
Mnod_2094
Chloride channel core; PFAM: CBS domain containing protein; Chloride channel core; KEGG: met:M446_5812 chloride channel core.
 
 
 0.576
Mnod_0501
Transcriptional regulator, AraC family; TIGRFAM: methylated-DNA/protein-cysteine methyltransferase; PFAM: helix-turn-helix- domain containing protein AraC type; Ada metal-binding domain protein; Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; KEGG: met:M446_1042 AraC family transcriptional regulator.
  
  
 0.542
Mnod_4538
PAS/PAC sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: met:M446_3255 multi-sensor hybrid histidine kinase.
     
 0.523
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.520
Mnod_5419
KEGG: met:M446_0210 PAS/PAC sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; SMART: PAS domain containing protein.
 
   
 0.512
hpf
Sigma 54 modulation protein/ribosomal protein S30EA; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
  
  
 0.509
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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