STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Mnod_3403PFAM: Formaldehyde-activating enzyme (Fae); KEGG: mpo:Mpop_3340 formaldehyde-activating enzyme (Fae). (182 aa)    
Predicted Functional Partners:
ffsA
Formylmethanofuran/tetrahydromethanopterin N-formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family.
 
  
 0.986
Mnod_6002
PFAM: Methylene-tetrahydromethanopterin dehydrogenase; KEGG: met:M446_5778 methylene-tetrahydromethanopterin dehydrogenase.
  
  
 0.979
Mnod_7114
PFAM: Methylene-tetrahydromethanopterin dehydrogenase; KEGG: met:M446_6554 methylenetetrahydrofolate dehydrogenase (NADP(+)).
  
  
 0.979
Mnod_6007
TIGRFAM: formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae); KEGG: met:M446_5783 formaldehyde-activating enzyme.
  
  
 
0.927
Mnod_5977
TIGRFAM: PQQ-dependent dehydrogenase, methanol/ethanol family; PFAM: Pyrrolo-quinoline quinone; KEGG: met:M446_5752 methanol/ethanol family PQQ-dependent dehydrogenase.
  
  
 0.923
Mnod_0421
TIGRFAM: PQQ-dependent dehydrogenase, methanol/ethanol family; PFAM: Pyrrolo-quinoline quinone; KEGG: met:M446_2082 methanol/ethanol family PQQ-dependent dehydrogenase.
  
  
 0.919
Mnod_2345
PFAM: extracellular solute-binding protein family 3; KEGG: met:M446_2993 extracellular solute-binding protein.
  
  
  0.919
Mnod_4915
TIGRFAM: formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae); KEGG: met:M446_4369 formaldehyde-activating enzyme.
  
  
 
0.913
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.911
glyA-2
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.911
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.