Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tsaDMetalloendopeptidase, glycoprotease family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (349 aa)    
Predicted Functional Partners:
Mnod_4430
PFAM: peptidase M22 glycoprotease; KEGG: met:M446_3393 peptidase M22 glycoprotease.
  
 
 0.949
Mnod_1606
PFAM: aminoglycoside phosphotransferase; protein of unknown function UPF0079; protein of unknown function DUF227; KEGG: met:M446_0493 aminoglycoside phosphotransferase.
 
 
 0.932
Mnod_4466
PFAM: GCN5-related N-acetyltransferase; KEGG: met:M446_4532 GCN5-related N-acetyltransferase.
  
  
 0.870
gpsA
PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: met:M446_4531 glycerol-3-phosphate dehydrogenase (NAD(P)(+)).
       0.853
Mnod_4468
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.770
pheS
TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; KEGG: met:M446_5319 phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
 
   
 0.758
pheT
TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: met:M446_5318 phenylalanyl-tRNA synthetase, beta subunit.
 
   
 0.745
rpsB
PFAM: ribosomal protein S2; KEGG: met:M446_4827 ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.
 
  
 0.697
rpsH
Ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.
  
  
 0.689
leuS
TIGRFAM: leucyl-tRNA synthetase; KEGG: met:M446_1404 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.670
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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