Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Mnod_4757KEGG: met:M446_4248 hypothetical protein. (178 aa)    
Predicted Functional Partners:
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
       0.746
Mnod_6945
PFAM: protein of unknown function DUF983; KEGG: mrd:Mrad2831_3291 hypothetical protein.
  
     0.705
Mnod_0266
PFAM: protein of unknown function DUF983; KEGG: met:M446_2343 hypothetical protein.
  
     0.689
Mnod_7412
PFAM: protein of unknown function DUF983; KEGG: met:M446_6673 hypothetical protein.
  
     0.570
Mnod_4143
PFAM: protein of unknown function DUF1467; KEGG: met:M446_4407 hypothetical protein.
  
     0.514
Mnod_0172
KEGG: met:M446_4587 hypothetical protein.
  
     0.508
Mnod_1835
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: met:M446_4889 integral membrane sensor signal transduction histidine kinase.
  
     0.490
Mnod_4517
KEGG: met:M446_3666 hypothetical protein.
  
     0.443
Mnod_1441
Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
       0.435
Mnod_6363
PFAM: AsmA family protein; KEGG: met:M446_5855 AsmA family protein.
  
     0.419
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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