STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
acsAacetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)    
Predicted Functional Partners:
Mnod_1524
TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: met:M446_0646 citrate synthase I; Belongs to the citrate synthase family.
  
 0.940
Mnod_4781
TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: met:M446_5280 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.937
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
   
 0.933
Mnod_0409
PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase; KEGG: met:M446_6099 phosphate butyryltransferase.
  
 
 0.929
Mnod_3983
PFAM: AMP-dependent synthetase and ligase; KEGG: rha:RHA1_ro06598 acetate--CoA ligase.
  
  
 
0.923
Mnod_1158
PFAM: AMP-dependent synthetase and ligase; KEGG: met:M446_2199 AMP-dependent synthetase and ligase.
  
  
 
0.920
Mnod_3077
PFAM: Thiolase; KEGG: mrd:Mrad2831_0689 propanoyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.919
Mnod_3980
TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: rsq:Rsph17025_3940 hypothetical protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.919
Mnod_5240
TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: met:M446_3279 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.919
Mnod_6744
PFAM: Thiolase; KEGG: met:M446_6598 propanoyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.919
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.