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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mnod_5259KEGG: mrd:Mrad2831_1495 adenylate/guanylate cyclase. (430 aa)    
Predicted Functional Partners:
cpdA
Metallophosphoesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
  
  
 0.916
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.904
Mnod_0033
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
  0.900
Mnod_6550
TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: met:M446_5947 MazG family protein.
     
  0.900
Mnod_4405
PFAM: cyclic nucleotide-binding; KEGG: met:M446_2719 cyclic nucleotide-binding protein.
 
 
 0.776
Mnod_2387
Adenylate/guanylate cyclase with integral membrane sensor; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; histidine kinase HAMP region domain protein; KEGG: met:M446_6425 adenylate/guanylate cyclase with integral membrane sensor.
  
     0.770
Mnod_0812
KEGG: met:M446_3613 putative adenylate/guanylate cyclase.
  
     0.766
Mnod_4159
KEGG: met:M446_4423 putative adenylate/guanylate cyclase.
  
     0.754
Mnod_6499
PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; Tetratricopeptide TPR_4; KEGG: met:M446_5885 adenylate/guanylate cyclase.
 
  
 0.737
Mnod_0276
KEGG: met:M446_2334 beta-lactamase domain-containing protein.
 
     0.719
Your Current Organism:
Methylobacterium nodulans
NCBI taxonomy Id: 460265
Other names: M. nodulans ORS 2060, Methylobacterium nodulans ORS 2060, Methylobacterium nodulans str. ORS 2060, Methylobacterium nodulans strain ORS 2060
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