STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACMD2_08402Tyrosyl-DNA phosphodiesterase 1. (618 aa)    
Predicted Functional Partners:
ACMD2_18646
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.934
ACMD2_20342
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.934
ACMD2_10904
Ubiquitin and WLM domain-containing metalloprotease.
    
 
 0.893
ACMD2_01424
Transcription factor bHLH140.
    
 
 0.888
ACMD2_09216
Transcription factor LAX PANICLE.
    
 
 0.888
ACMD2_16230
Transcription factor LAX PANICLE.
    
 
 0.888
ACMD2_05530
ATP-dependent DNA helicase 2 subunit KU80; Single-stranded DNA-dependent ATP-dependent helicase.
  
 
 0.881
ACMD2_18891
DNA ligase 1.
   
 0.864
ACMD2_22971
Uncharacterized protein.
   
 0.864
ACMD2_23419
DNA cross-link repair 1 protein.
   
 0.864
Your Current Organism:
Ananas comosus
NCBI taxonomy Id: 4615
Other names: A. comosus, Ananas comosus var. comosus, Ananas lucidus, pineapple
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