SEK39967.1 protein (Nonomuraea pusilla) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SEK39967.1

Two-component system, OmpR family, sensor histidine kinase MtrB. (470 aa)

Predicted Functional Partners:

SEK40001.1

0.990

SEM79517.1

0.974

SEL47850.1

0.965

SEN00202.1

0.956

SEN12233.1

0.903

SEL41774.1

0.902

SEN40830.1

0.898

SEK88548.1

0.897

SEL42627.1

0.897

SEL70134.1

0.897

Your Current Organism:

Nonomuraea pusilla

NCBI taxonomy Id: 46177
Other names: ATCC 27296, Actinomadura pusilla, BCRC 11619, CBS 262.72, CCRC 11619, CCRC:11619, CECT 3284, CIP 106954, DSM 43357, IFO 14684, IMET 9586, JCM 3144, KCTC 9278, Microtetraspora pusilla, N. pusilla, NBRC 14684, NCIMB 11116, NRRL B-16126, Nonomuria pusilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEK39967.1	SEK40001.1	SAMN05660976_00454	SAMN05660976_00455	Two-component system, OmpR family, sensor histidine kinase MtrB.	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	0.990
SEK39967.1	SEK88548.1	SAMN05660976_00454	SAMN05660976_01321	Two-component system, OmpR family, sensor histidine kinase MtrB.	Two-component system, OmpR family, response regulator PrrA.	0.897
SEK39967.1	SEL41774.1	SAMN05660976_00454	SAMN05660976_02380	Two-component system, OmpR family, sensor histidine kinase MtrB.	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	0.902
SEK39967.1	SEL42627.1	SAMN05660976_00454	SAMN05660976_02408	Two-component system, OmpR family, sensor histidine kinase MtrB.	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	0.897
SEK39967.1	SEL47850.1	SAMN05660976_00454	SAMN05660976_02568	Two-component system, OmpR family, sensor histidine kinase MtrB.	Hypothetical protein.	0.965
SEK39967.1	SEL70134.1	SAMN05660976_00454	SAMN05660976_03141	Two-component system, OmpR family, sensor histidine kinase MtrB.	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	0.897
SEK39967.1	SEM79517.1	SAMN05660976_00454	SAMN05660976_06073	Two-component system, OmpR family, sensor histidine kinase MtrB.	Two-component system, OmpR family, response regulator MtrA.	0.974
SEK39967.1	SEN00202.1	SAMN05660976_00454	SAMN05660976_06595	Two-component system, OmpR family, sensor histidine kinase MtrB.	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	0.956
SEK39967.1	SEN12233.1	SAMN05660976_00454	SAMN05660976_06847	Two-component system, OmpR family, sensor histidine kinase MtrB.	Response regulator receiver domain-containing protein.	0.903
SEK39967.1	SEN40830.1	SAMN05660976_00454	SAMN05660976_07485	Two-component system, OmpR family, sensor histidine kinase MtrB.	Two-component system, OmpR family, response regulator RegX3.	0.898
SEK40001.1	SEK39967.1	SAMN05660976_00455	SAMN05660976_00454	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	Two-component system, OmpR family, sensor histidine kinase MtrB.	0.990
SEK40001.1	SEL47850.1	SAMN05660976_00455	SAMN05660976_02568	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	Hypothetical protein.	0.991
SEK40001.1	SEM79517.1	SAMN05660976_00455	SAMN05660976_06073	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	Two-component system, OmpR family, response regulator MtrA.	0.750
SEK88548.1	SEK39967.1	SAMN05660976_01321	SAMN05660976_00454	Two-component system, OmpR family, response regulator PrrA.	Two-component system, OmpR family, sensor histidine kinase MtrB.	0.897
SEK88548.1	SEL47850.1	SAMN05660976_01321	SAMN05660976_02568	Two-component system, OmpR family, response regulator PrrA.	Hypothetical protein.	0.991
SEL41774.1	SEK39967.1	SAMN05660976_02380	SAMN05660976_00454	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	Two-component system, OmpR family, sensor histidine kinase MtrB.	0.902
SEL41774.1	SEL47850.1	SAMN05660976_02380	SAMN05660976_02568	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	Hypothetical protein.	0.991
SEL42627.1	SEK39967.1	SAMN05660976_02408	SAMN05660976_00454	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	Two-component system, OmpR family, sensor histidine kinase MtrB.	0.897
SEL42627.1	SEL47850.1	SAMN05660976_02408	SAMN05660976_02568	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	Hypothetical protein.	0.991
SEL42627.1	SEL70134.1	SAMN05660976_02408	SAMN05660976_03141	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain.	0.694

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

33

PPI enrichment p-value:

9.21e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 106

1.46

2.69

1.87e-11

GO:0010467

Gene expression

11 of 221

1.18

1.79

3.26e-11

GO:0044260

Cellular macromolecule metabolic process

11 of 392

0.93

1.1

7.75e-09

GO:0034641

Cellular nitrogen compound metabolic process

11 of 612

0.74

0.73

6.79e-07

GO:0044238

Primary metabolic process

11 of 1142

0.47

0.4

0.00040

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 53

1.76

4.31

1.72e-14

GO:0019843

rRNA binding

4 of 41

1.47

1.18

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 56

1.74

4.28

5.58e-15

GO:0044391

Ribosomal subunit

2 of 15

1.61

0.81

0.0228

GO:0005622

Intracellular anatomical structure

11 of 1225

0.44

0.38

0.00033

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32228805

(2020) Lactobacillus garii sp. nov., isolated from a fermented cassava product.

8 of 27

1.96

4.58

2.10e-12

PMID:36613254

(2022) Comparative Genomics Analysis Provides New Insights into High Ethanol Tolerance of Lactiplantibacillus pentosus LTJ12, a Novel Strain Isolated from Chinese Baijiu.

7 of 52

1.61

2.71

1.24e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:174

Ribosome

6 of 11

2.22

4.55

1.93e-10

CL:103

Ribosome, and Translation regulator activity

11 of 73

1.66

4.05

9.08e-16

CL:176

Ribosome

4 of 5

2.39

3.28

4.18e-07

CL:105

Structural constituent of ribosome, and Translation elongation factor activity

8 of 67

1.56

2.84

4.11e-10

CL:220

Mixed, incl. Small ribosomal subunit, and K homology domain superfamily, prokaryotic type

2 of 8

1.88

0.89

0.0192

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lpg03010

Ribosome

10 of 50

1.79

4.6

1.55e-15

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

8 of 44

1.74

3.53

7.51e-11

GOCC:0044391

Ribosomal subunit

4 of 23

1.72

1.92

4.42e-05

GOCC:0043229

Intracellular organelle

10 of 272

1.05

1.32

1.90e-08

GOCC:0015934

Large ribosomal subunit

2 of 10

1.79

0.89

0.0178

GOCC:0015935

Small ribosomal subunit

2 of 13

1.67

0.8

0.0253

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 54

1.75

4.35

5.98e-15

KW-0699

rRNA-binding

4 of 40

1.48

1.37

0.00048

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