SEK90225.1 protein (Nonomuraea pusilla) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

SEK90225.1

Putative Holin-X, holin superfamily III. (131 aa)

Predicted Functional Partners:

SEK90145.1

0.959

SEK90187.1

0.826

SEK90096.1

0.773

SEL84780.1

0.492

SEM66740.1

0.474

SEL06247.1

0.454

SEL98521.1

0.412

SEL68655.1

0.407

SEN36504.1

0.405

SEK41092.1

0.400

Your Current Organism:

Nonomuraea pusilla

NCBI taxonomy Id: 46177
Other names: ATCC 27296, Actinomadura pusilla, BCRC 11619, CBS 262.72, CCRC 11619, CCRC:11619, CECT 3284, CIP 106954, DSM 43357, IFO 14684, IMET 9586, JCM 3144, KCTC 9278, Microtetraspora pusilla, N. pusilla, NBRC 14684, NCIMB 11116, NRRL B-16126, Nonomuria pusilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEK41092.1	SEK90225.1	SAMN05660976_00482	SAMN05660976_01364	DNA-binding transcriptional regulator, ArsR family.	Putative Holin-X, holin superfamily III.	0.400
SEK90096.1	SEK90145.1	SAMN05660976_01361	SAMN05660976_01362	Chagasin family peptidase inhibitor I42.	Membrane protein.	0.773
SEK90096.1	SEK90187.1	SAMN05660976_01361	SAMN05660976_01363	Chagasin family peptidase inhibitor I42.	Protein of unknown function.	0.773
SEK90096.1	SEK90225.1	SAMN05660976_01361	SAMN05660976_01364	Chagasin family peptidase inhibitor I42.	Putative Holin-X, holin superfamily III.	0.773
SEK90145.1	SEK90096.1	SAMN05660976_01362	SAMN05660976_01361	Membrane protein.	Chagasin family peptidase inhibitor I42.	0.773
SEK90145.1	SEK90187.1	SAMN05660976_01362	SAMN05660976_01363	Membrane protein.	Protein of unknown function.	0.793
SEK90145.1	SEK90225.1	SAMN05660976_01362	SAMN05660976_01364	Membrane protein.	Putative Holin-X, holin superfamily III.	0.959
SEK90187.1	SEK90096.1	SAMN05660976_01363	SAMN05660976_01361	Protein of unknown function.	Chagasin family peptidase inhibitor I42.	0.773
SEK90187.1	SEK90145.1	SAMN05660976_01363	SAMN05660976_01362	Protein of unknown function.	Membrane protein.	0.793
SEK90187.1	SEK90225.1	SAMN05660976_01363	SAMN05660976_01364	Protein of unknown function.	Putative Holin-X, holin superfamily III.	0.826
SEK90225.1	SEK41092.1	SAMN05660976_01364	SAMN05660976_00482	Putative Holin-X, holin superfamily III.	DNA-binding transcriptional regulator, ArsR family.	0.400
SEK90225.1	SEK90096.1	SAMN05660976_01364	SAMN05660976_01361	Putative Holin-X, holin superfamily III.	Chagasin family peptidase inhibitor I42.	0.773
SEK90225.1	SEK90145.1	SAMN05660976_01364	SAMN05660976_01362	Putative Holin-X, holin superfamily III.	Membrane protein.	0.959
SEK90225.1	SEK90187.1	SAMN05660976_01364	SAMN05660976_01363	Putative Holin-X, holin superfamily III.	Protein of unknown function.	0.826
SEK90225.1	SEL06247.1	SAMN05660976_01364	SAMN05660976_01765	Putative Holin-X, holin superfamily III.	Iron-containing redox enzyme.	0.454
SEK90225.1	SEL68655.1	SAMN05660976_01364	SAMN05660976_03086	Putative Holin-X, holin superfamily III.	Hypothetical protein.	0.407
SEK90225.1	SEL84780.1	SAMN05660976_01364	SAMN05660976_03524	Putative Holin-X, holin superfamily III.	Histidine kinase-like ATPase domain-containing protein.	0.492
SEK90225.1	SEL98521.1	SAMN05660976_01364	SAMN05660976_03890	Putative Holin-X, holin superfamily III.	Hypothetical protein.	0.412
SEK90225.1	SEM66740.1	SAMN05660976_01364	SAMN05660976_05726	Putative Holin-X, holin superfamily III.	Hypothetical protein.	0.474
SEK90225.1	SEN36504.1	SAMN05660976_01364	SAMN05660976_07395	Putative Holin-X, holin superfamily III.	Anti-sigma regulatory factor (Ser/Thr protein kinase).	0.405

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Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.787

expected number of edges:

10

PPI enrichment p-value:

0.0391

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

10 of 249

0.85

0.84

1.28e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042626

ATPase-coupled transmembrane transporter activity

5 of 57

1.19

1.12

0.00033

GO:0140359

ABC-type transporter activity

4 of 39

1.26

1.04

0.0016

GO:0005524

ATP binding

10 of 261

0.83

0.82

1.05e-05

GO:0022857

Transmembrane transporter activity

8 of 210

0.83

0.76

9.66e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

10 of 571

0.49

0.38

0.0041

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2923

Transcription regulators MarR/SlyA-like, and ABC transporter transmembrane region

4 of 5

2.15

2.51

9.61e-06

CL:2919

Mixed, incl. ABC transporter transmembrane region, and ABC transporter, CbiO/EcfA subunit

5 of 31

1.46

1.59

5.78e-05

CL:2914

Mixed, incl. ABC transporters, and Latent infection - Other responses of Mtb to phagocytosis

9 of 108

1.17

1.51

1.53e-07

CL:2915

Mixed, incl. ABC transporters, and Latent infection - Other responses of Mtb to phagocytosis

8 of 93

1.18

1.45

1.18e-06

CL:2916

Mixed, incl. Latent infection - Other responses of Mtb to phagocytosis, and ABC transporters

7 of 82

1.18

1.34

9.66e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

adc02010

ABC transporters

6 of 90

1.07

0.97

0.00042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222449

Mtb iron assimilation by chelation

2 of 15

1.37

0.62

0.0483

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005886

Plasma membrane

7 of 236

0.72

0.49

0.0111

GOCC:0016020

Membrane

8 of 319

0.65

0.45

0.0111

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1278

Translocase

3 of 10

1.73

1.29

0.0020

KW-0067

ATP-binding

10 of 211

0.92

1.02

4.39e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017871

ABC transporter-like, conserved site

10 of 60

1.47

2.74

1.49e-11

IPR003439

ABC transporter-like, ATP-binding domain

10 of 67

1.42

2.57

2.05e-11

IPR003593

AAA+ ATPase domain

10 of 84

1.32

2.18

1.12e-10

IPR027417

P-loop containing nucleoside triphosphate hydrolase

10 of 157

1.05

1.32

3.16e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

10 of 81

1.34

2.29

2.19e-11

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