SEK91688.1 protein (Nonomuraea pusilla) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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Databases

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[Homology]

Score

SEK91688.1

NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family. (249 aa)

Predicted Functional Partners:

SEK57810.1

0.926

SEK60190.1

0.888

SEK57977.1

0.870

SEN48877.1

0.865

SEM95930.1

0.837

SEN48978.1

0.837

SEK57894.1

0.801

SEK56881.1

0.771

SEM41794.1

0.771

SEK74279.1

0.767

Your Current Organism:

Nonomuraea pusilla

NCBI taxonomy Id: 46177
Other names: ATCC 27296, Actinomadura pusilla, BCRC 11619, CBS 262.72, CCRC 11619, CCRC:11619, CECT 3284, CIP 106954, DSM 43357, IFO 14684, IMET 9586, JCM 3144, KCTC 9278, Microtetraspora pusilla, N. pusilla, NBRC 14684, NCIMB 11116, NRRL B-16126, Nonomuria pusilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEK56881.1	SEK57810.1	SAMN05660976_00675	SAMN05660976_00698	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	Amino acid adenylation domain-containing protein.	0.926
SEK56881.1	SEK57894.1	SAMN05660976_00675	SAMN05660976_00700	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	Amino acid adenylation domain-containing protein.	0.801
SEK56881.1	SEK57977.1	SAMN05660976_00675	SAMN05660976_00702	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	Amino acid adenylation domain-containing protein.	0.870
SEK56881.1	SEK60190.1	SAMN05660976_00675	SAMN05660976_00760	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	Thioesterase domain-containing protein.	0.888
SEK56881.1	SEK91688.1	SAMN05660976_00675	SAMN05660976_01403	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	0.771
SEK56881.1	SEM95930.1	SAMN05660976_00675	SAMN05660976_06471	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	Amino acid adenylation domain-containing protein.	0.837
SEK56881.1	SEN48877.1	SAMN05660976_00675	SAMN05660976_07689	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	Glycine C-acetyltransferase.	0.865
SEK56881.1	SEN48978.1	SAMN05660976_00675	SAMN05660976_07692	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	Phosphopantetheine attachment site.	0.837
SEK57810.1	SEK56881.1	SAMN05660976_00698	SAMN05660976_00675	Amino acid adenylation domain-containing protein.	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	0.926
SEK57810.1	SEK57894.1	SAMN05660976_00698	SAMN05660976_00700	Amino acid adenylation domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999
SEK57810.1	SEK57977.1	SAMN05660976_00698	SAMN05660976_00702	Amino acid adenylation domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999
SEK57810.1	SEK60190.1	SAMN05660976_00698	SAMN05660976_00760	Amino acid adenylation domain-containing protein.	Thioesterase domain-containing protein.	0.999
SEK57810.1	SEK74279.1	SAMN05660976_00698	SAMN05660976_01132	Amino acid adenylation domain-containing protein.	3-oxoacyl-[acyl-carrier protein] reductase.	0.926
SEK57810.1	SEK91688.1	SAMN05660976_00698	SAMN05660976_01403	Amino acid adenylation domain-containing protein.	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	0.926
SEK57810.1	SEM41794.1	SAMN05660976_00698	SAMN05660976_05069	Amino acid adenylation domain-containing protein.	3-oxoacyl-[acyl-carrier protein] reductase.	0.926
SEK57810.1	SEM95930.1	SAMN05660976_00698	SAMN05660976_06471	Amino acid adenylation domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999
SEK57810.1	SEN48877.1	SAMN05660976_00698	SAMN05660976_07689	Amino acid adenylation domain-containing protein.	Glycine C-acetyltransferase.	0.999
SEK57810.1	SEN48978.1	SAMN05660976_00698	SAMN05660976_07692	Amino acid adenylation domain-containing protein.	Phosphopantetheine attachment site.	0.999
SEK57894.1	SEK56881.1	SAMN05660976_00700	SAMN05660976_00675	Amino acid adenylation domain-containing protein.	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family.	0.801
SEK57894.1	SEK57810.1	SAMN05660976_00700	SAMN05660976_00698	Amino acid adenylation domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.841

expected number of edges:

15

PPI enrichment p-value:

0.103

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005975

Carbohydrate metabolic process

9 of 207

1.14

1.4

6.82e-07

GO:0005976

Polysaccharide metabolic process

5 of 57

1.45

1.36

0.00040

GO:0009225

Nucleotide-sugar metabolic process

3 of 18

1.73

1.08

0.0064

GO:0034637

Cellular carbohydrate biosynthetic process

4 of 46

1.44

1.06

0.0036

GO:0016051

Carbohydrate biosynthetic process

5 of 90

1.25

0.99

0.0023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016779

Nucleotidyltransferase activity

5 of 51

1.5

1.45

0.00026

GO:0016868

Intramolecular transferase activity, phosphotransferases

2 of 5

2.11

0.73

0.0446

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2438

O-Antigen nucleotide sugar biosynthesis, and Alpha-D-phosphohexomutase, C-terminal

5 of 16

2.0

2.98

3.33e-07

CL:2431

Mixed, incl. Polysaccharide metabolic process, and O-Antigen nucleotide sugar biosynthesis

9 of 83

1.54

2.83

1.64e-10

CL:2439

O-Antigen nucleotide sugar biosynthesis

4 of 8

2.2

2.8

2.57e-06

CL:2434

Mixed, incl. O-Antigen nucleotide sugar biosynthesis, and Polysaccharide biosynthetic process

6 of 50

1.58

2.25

7.27e-07

CL:2565

Glucan metabolic process, and Disaccharide metabolic process

3 of 10

1.98

1.68

0.00043

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00541

O-Antigen nucleotide sugar biosynthesis

6 of 22

1.94

3.56

4.04e-09

map00520

Amino sugar and nucleotide sugar metabolism

8 of 52

1.69

3.36

8.78e-11

map00500

Starch and sucrose metabolism

6 of 33

1.76

2.98

2.30e-08

map00052

Galactose metabolism

3 of 22

1.64

1.32

0.0013

map00521

Streptomycin biosynthesis

2 of 17

1.57

0.77

0.0265

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0548

Nucleotidyltransferase

4 of 42

1.48

1.19

0.0017

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12804

MobA-like NTP transferase domain

4 of 9

2.15

2.36

2.07e-05

PF02880

Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III

2 of 3

2.33

0.87

0.0251

PF02879

Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II

2 of 3

2.33

0.87

0.0251

PF02878

Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I

2 of 3

2.33

0.87

0.0251

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005835

Nucleotidyl transferase domain

4 of 6

2.33

2.65

7.64e-06

IPR029044

Nucleotide-diphospho-sugar transferases

6 of 37

1.71

2.38

1.45e-06

IPR036900

Alpha-D-phosphohexomutase, C-terminal domain superfamily

2 of 3

2.33

0.75

0.0419

IPR016066

Alpha-D-phosphohexomutase, conserved site

2 of 3

2.33

0.75

0.0419

IPR016055

Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III

2 of 3

2.33

0.75

0.0419

(more ...)

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