SEL20709.1 protein (Nonomuraea pusilla) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Score

SEL20709.1

Hypothetical protein. (249 aa)

Predicted Functional Partners:

SEL20742.1

0.810

SEL20777.1

0.752

SEM24281.1

0.681

SEL20899.1

0.601

SEN44102.1

0.574

SEK97772.1

0.570

SEK38497.1

0.534

SEL41997.1

0.499

SEN05884.1

0.496

SEN44058.1

0.484

Your Current Organism:

Nonomuraea pusilla

NCBI taxonomy Id: 46177
Other names: ATCC 27296, Actinomadura pusilla, BCRC 11619, CBS 262.72, CCRC 11619, CCRC:11619, CECT 3284, CIP 106954, DSM 43357, IFO 14684, IMET 9586, JCM 3144, KCTC 9278, Microtetraspora pusilla, N. pusilla, NBRC 14684, NCIMB 11116, NRRL B-16126, Nonomuria pusilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEK38497.1	SEL20709.1	SAMN05660976_00416	SAMN05660976_01976	Cystathionine beta-synthase.	Hypothetical protein.	0.534
SEK38497.1	SEM24281.1	SAMN05660976_00416	SAMN05660976_04561	Cystathionine beta-synthase.	Carboxylate-amine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.	0.762
SEK97772.1	SEL20709.1	SAMN05660976_01565	SAMN05660976_01976	Membrane protein.	Hypothetical protein.	0.570
SEL20709.1	SEK38497.1	SAMN05660976_01976	SAMN05660976_00416	Hypothetical protein.	Cystathionine beta-synthase.	0.534
SEL20709.1	SEK97772.1	SAMN05660976_01976	SAMN05660976_01565	Hypothetical protein.	Membrane protein.	0.570
SEL20709.1	SEL20742.1	SAMN05660976_01976	SAMN05660976_01977	Hypothetical protein.	STE24 endopeptidase.	0.810
SEL20709.1	SEL20777.1	SAMN05660976_01976	SAMN05660976_01978	Hypothetical protein.	Phosphatidylinositol alpha-1,6-mannosyltransferase.	0.752
SEL20709.1	SEL20899.1	SAMN05660976_01976	SAMN05660976_01981	Hypothetical protein.	Polyketide cyclase / dehydrase and lipid transport.	0.601
SEL20709.1	SEL41997.1	SAMN05660976_01976	SAMN05660976_02387	Hypothetical protein.	Alpha-1,2-mannosyltransferase.	0.499
SEL20709.1	SEM24281.1	SAMN05660976_01976	SAMN05660976_04561	Hypothetical protein.	Carboxylate-amine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.	0.681
SEL20709.1	SEN05884.1	SAMN05660976_01976	SAMN05660976_06717	Hypothetical protein.	Protein of unknown function.	0.496
SEL20709.1	SEN44058.1	SAMN05660976_01976	SAMN05660976_07587	Hypothetical protein.	Mce-associated membrane protein.	0.484
SEL20709.1	SEN44102.1	SAMN05660976_01976	SAMN05660976_07588	Hypothetical protein.	Mce-associated membrane protein.	0.574
SEL20742.1	SEL20709.1	SAMN05660976_01977	SAMN05660976_01976	STE24 endopeptidase.	Hypothetical protein.	0.810
SEL20742.1	SEL20777.1	SAMN05660976_01977	SAMN05660976_01978	STE24 endopeptidase.	Phosphatidylinositol alpha-1,6-mannosyltransferase.	0.773
SEL20777.1	SEL20709.1	SAMN05660976_01978	SAMN05660976_01976	Phosphatidylinositol alpha-1,6-mannosyltransferase.	Hypothetical protein.	0.752
SEL20777.1	SEL20742.1	SAMN05660976_01978	SAMN05660976_01977	Phosphatidylinositol alpha-1,6-mannosyltransferase.	STE24 endopeptidase.	0.773
SEL20899.1	SEL20709.1	SAMN05660976_01981	SAMN05660976_01976	Polyketide cyclase / dehydrase and lipid transport.	Hypothetical protein.	0.601
SEL41997.1	SEL20709.1	SAMN05660976_02387	SAMN05660976_01976	Alpha-1,2-mannosyltransferase.	Hypothetical protein.	0.499
SEM24281.1	SEK38497.1	SAMN05660976_04561	SAMN05660976_00416	Carboxylate-amine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.	Cystathionine beta-synthase.	0.762

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

13

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006090

Pyruvate metabolic process

5 of 26

1.78

2.08

2.13e-05

GO:0045454

Cell redox homeostasis

3 of 9

2.02

1.57

0.00084

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

2 of 2

2.5

1.37

0.0030

GO:0006096

Glycolytic process

3 of 18

1.72

1.22

0.0030

GO:0009150

Purine ribonucleotide metabolic process

5 of 79

1.3

1.15

0.00076

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

5 of 7

2.35

3.66

5.65e-08

GO:0004739

Pyruvate dehydrogenase (acetyl-transferring) activity

4 of 6

2.32

2.79

3.70e-06

GO:0016417

S-acyltransferase activity

2 of 4

2.2

0.99

0.0147

GO:0050660

Flavin adenine dinucleotide binding

3 of 37

1.41

0.77

0.0204

GO:0016491

Oxidoreductase activity

8 of 380

0.82

0.71

0.00036

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1404

Pyruvate dehydrogenase activity, and e3 binding domain

9 of 13

2.34

7.17

1.15e-16

CL:1406

Pyruvate dehydrogenase activity, and Peptidyl-lysine modification

5 of 5

2.5

4.42

2.31e-09

CL:1367

Mixed, incl. Citrate cycle (TCA cycle), and Oxidoreduction-driven active transmembrane transporter activity

10 of 68

1.66

3.81

5.55e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mvd00020

Citrate cycle (TCA cycle)

7 of 33

1.82

3.53

6.31e-10

mvd00620

Pyruvate metabolism

6 of 54

1.54

2.23

3.78e-07

mvd00010

Glycolysis / Gluconeogenesis

6 of 56

1.53

2.2

3.78e-07

mvd01200

Carbon metabolism

8 of 123

1.31

1.9

3.18e-08

mvd01120

Microbial metabolism in diverse environments

9 of 342

0.92

0.99

1.17e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

5 of 17

1.97

2.85

5.77e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00676

Dehydrogenase E1 component

3 of 3

2.5

1.96

0.00023

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 3

2.32

0.9

0.0220

PF02780

Transketolase, C-terminal domain

2 of 4

2.2

0.89

0.0220

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

2 of 4

2.2

0.89

0.0220

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 5

2.1

0.89

0.0220

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 14

2.05

2.76

1.62e-06

IPR001017

Dehydrogenase, E1 component

3 of 3

2.5

1.9

0.00030

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

3 of 4

2.37

1.84

0.00035

IPR005475

Transketolase-like, pyrimidine-binding domain

3 of 6

2.2

1.67

0.00063

IPR023753

FAD/NAD(P)-binding domain

3 of 12

1.89

1.29

0.0027

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

3 of 6

2.2

1.92

0.00020

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