SEM16924.1 protein (Nonomuraea pusilla) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SEM16924.1

ABC-2 type transport system ATP-binding protein. (333 aa)

Predicted Functional Partners:

SEM16885.1

0.966

SEK92090.1

0.842

SEK65892.1

0.823

SEM59397.1

0.823

SEM17664.1

0.804

SEL48829.1

0.802

SEM38461.1

0.801

SEM61946.1

0.798

SEM63481.1

0.769

SEM16940.1

0.550

Your Current Organism:

Nonomuraea pusilla

NCBI taxonomy Id: 46177
Other names: ATCC 27296, Actinomadura pusilla, BCRC 11619, CBS 262.72, CCRC 11619, CCRC:11619, CECT 3284, CIP 106954, DSM 43357, IFO 14684, IMET 9586, JCM 3144, KCTC 9278, Microtetraspora pusilla, N. pusilla, NBRC 14684, NCIMB 11116, NRRL B-16126, Nonomuria pusilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEK65892.1	SEK92090.1	SAMN05660976_00932	SAMN05660976_01413	Oleandomycin transport system permease protein.	ABC-2 type transport system permease protein.	0.762
SEK65892.1	SEL48829.1	SAMN05660976_00932	SAMN05660976_02601	Oleandomycin transport system permease protein.	ABC transporter efflux protein, DrrB family.	0.477
SEK65892.1	SEM16885.1	SAMN05660976_00932	SAMN05660976_04373	Oleandomycin transport system permease protein.	ABC-type multidrug transport system, permease component.	0.744
SEK65892.1	SEM16924.1	SAMN05660976_00932	SAMN05660976_04374	Oleandomycin transport system permease protein.	ABC-2 type transport system ATP-binding protein.	0.823
SEK65892.1	SEM17664.1	SAMN05660976_00932	SAMN05660976_04402	Oleandomycin transport system permease protein.	ABC-2 type transport system permease protein.	0.570
SEK65892.1	SEM38461.1	SAMN05660976_00932	SAMN05660976_05018	Oleandomycin transport system permease protein.	ABC-2 type transport system permease protein.	0.577
SEK65892.1	SEM59397.1	SAMN05660976_00932	SAMN05660976_05527	Oleandomycin transport system permease protein.	ABC-2 type transport system permease protein.	0.407
SEK65892.1	SEM61946.1	SAMN05660976_00932	SAMN05660976_05625	Oleandomycin transport system permease protein.	ABC-2 type transport system permease protein.	0.571
SEK65892.1	SEM63481.1	SAMN05660976_00932	SAMN05660976_05685	Oleandomycin transport system permease protein.	ABC-2 type transport system permease protein.	0.515
SEK92090.1	SEK65892.1	SAMN05660976_01413	SAMN05660976_00932	ABC-2 type transport system permease protein.	Oleandomycin transport system permease protein.	0.762
SEK92090.1	SEL48829.1	SAMN05660976_01413	SAMN05660976_02601	ABC-2 type transport system permease protein.	ABC transporter efflux protein, DrrB family.	0.707
SEK92090.1	SEM16885.1	SAMN05660976_01413	SAMN05660976_04373	ABC-2 type transport system permease protein.	ABC-type multidrug transport system, permease component.	0.797
SEK92090.1	SEM16924.1	SAMN05660976_01413	SAMN05660976_04374	ABC-2 type transport system permease protein.	ABC-2 type transport system ATP-binding protein.	0.842
SEK92090.1	SEM17664.1	SAMN05660976_01413	SAMN05660976_04402	ABC-2 type transport system permease protein.	ABC-2 type transport system permease protein.	0.540
SEK92090.1	SEM38461.1	SAMN05660976_01413	SAMN05660976_05018	ABC-2 type transport system permease protein.	ABC-2 type transport system permease protein.	0.532
SEK92090.1	SEM59397.1	SAMN05660976_01413	SAMN05660976_05527	ABC-2 type transport system permease protein.	ABC-2 type transport system permease protein.	0.758
SEK92090.1	SEM61946.1	SAMN05660976_01413	SAMN05660976_05625	ABC-2 type transport system permease protein.	ABC-2 type transport system permease protein.	0.528
SEK92090.1	SEM63481.1	SAMN05660976_01413	SAMN05660976_05685	ABC-2 type transport system permease protein.	ABC-2 type transport system permease protein.	0.722
SEL48829.1	SEK65892.1	SAMN05660976_02601	SAMN05660976_00932	ABC transporter efflux protein, DrrB family.	Oleandomycin transport system permease protein.	0.477
SEL48829.1	SEK92090.1	SAMN05660976_02601	SAMN05660976_01413	ABC transporter efflux protein, DrrB family.	ABC-2 type transport system permease protein.	0.707

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Network Stats

number of nodes:

7

number of edges:

11

average node degree:

3.14

avg. local clustering coefficient:

0.857

expected number of edges:

6

PPI enrichment p-value:

0.0474

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018345

Protein palmitoylation

5 of 35

2.41

3.53

1.32e-07

GO:0018230

peptidyl-L-cysteine S-palmitoylation

4 of 24

2.48

2.81

4.59e-06

GO:0070200

Establishment of protein localization to telomere

2 of 5

2.86

1.29

0.0046

GO:0032202

Telomere assembly

2 of 5

2.86

1.29

0.0046

GO:0061820

Telomeric D-loop disassembly

2 of 7

2.71

1.23

0.0058

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019706

Protein-cysteine S-palmitoyltransferase activity

3 of 29

2.27

1.45

0.0019

GO:0062037

D-loop DNA binding

2 of 5

2.86

1.36

0.0035

GO:0032357

Oxidized purine DNA binding

2 of 11

2.51

1.07

0.0110

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070187

Shelterin complex

2 of 7

2.71

1.0

0.0155

GO:0002178

Palmitoyltransferase complex

2 of 11

2.51

0.99

0.0155

GO:0000781

Chromosome, telomeric region

3 of 104

1.71

0.91

0.0155

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20205

peptidyl-L-cysteine S-palmitoylation, and Regulation of protein localization to phagocytic vesicle

5 of 12

2.87

5.0

4.84e-10

CL:20206

DHHC palmitoyltransferase

3 of 6

2.95

2.8

7.63e-06

CL:13601

Shelterin complex

2 of 5

2.86

1.35

0.0036

CL:20217

Mixed, incl. Golgin subfamily A member 7/ERF4 family, and Regulation of protein localization to phagocytic vesicle

2 of 6

2.78

1.31

0.0042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-174437

Removal of the Flap Intermediate from the C-strand

3 of 18

2.48

1.9

0.00029

MAP-174414

Processive synthesis on the C-strand of the telomere

3 of 20

2.43

1.89

0.00029

MAP-174417

Telomere C-strand (Lagging Strand) Synthesis

3 of 37

2.16

1.64

0.00071

MAP-180786

Extension of Telomeres

3 of 64

1.92

1.31

0.0026

MAP-174430

Telomere C-strand synthesis initiation

2 of 14

2.41

1.1

0.0095

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0002178

Palmitoyltransferase complex

2 of 10

2.55

0.81

0.0334

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0012

Acyltransferase

3 of 69

1.89

1.3

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01529

DHHC palmitoyltransferase

3 of 23

2.37

1.67

0.00075

PF10256

Golgin subfamily A member 7/ERF4 family

2 of 4

2.95

1.28

0.0048

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001594

Palmitoyltransferase, DHHC domain

3 of 23

2.37

1.42

0.0023

IPR019383

Golgin subfamily A member 7/ERF4

2 of 4

2.95

1.01

0.0148

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