SEN19843.1 protein (Nonomuraea pusilla) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

SEN19843.1

Cobaltochelatase CobN subunit. (1203 aa)

Predicted Functional Partners:

SEN19925.1

0.995

cobB-2

0.989

SEN19949.1

0.989

SEN19727.1

0.958

SEN19618.1

0.946

SEN19693.1

0.940

SEN19754.1

0.931

SEL19210.1

0.918

cobD

0.909

SEN19658.1

0.906

Your Current Organism:

Nonomuraea pusilla

NCBI taxonomy Id: 46177
Other names: ATCC 27296, Actinomadura pusilla, BCRC 11619, CBS 262.72, CCRC 11619, CCRC:11619, CECT 3284, CIP 106954, DSM 43357, IFO 14684, IMET 9586, JCM 3144, KCTC 9278, Microtetraspora pusilla, N. pusilla, NBRC 14684, NCIMB 11116, NRRL B-16126, Nonomuria pusilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEL19210.1	SEN19618.1	SAMN05660976_01933	SAMN05660976_07006	Adenosylcobinamide kinase.	precorrin-6Y C5,15-methyltransferase (decarboxylating).	0.842
SEL19210.1	SEN19658.1	SAMN05660976_01933	SAMN05660976_07007	Adenosylcobinamide kinase.	Precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family.	0.947
SEL19210.1	SEN19693.1	SAMN05660976_01933	SAMN05660976_07008	Adenosylcobinamide kinase.	precorrin-6A reductase.	0.881
SEL19210.1	SEN19727.1	SAMN05660976_01933	SAMN05660976_07009	Adenosylcobinamide kinase.	Precorrin-3 methyltransferase.	0.957
SEL19210.1	SEN19754.1	SAMN05660976_01933	SAMN05660976_07010	Adenosylcobinamide kinase.	precorrin-8X methylmutase.	0.878
SEL19210.1	SEN19843.1	SAMN05660976_01933	SAMN05660976_07013	Adenosylcobinamide kinase.	Cobaltochelatase CobN subunit.	0.918
SEL19210.1	SEN19925.1	SAMN05660976_01933	SAMN05660976_07015	Adenosylcobinamide kinase.	cob(I)alamin adenosyltransferase.	0.989
SEL19210.1	SEN19949.1	SAMN05660976_01933	SAMN05660976_07016	Adenosylcobinamide kinase.	Protoporphyrin IX magnesium-chelatase.	0.435
SEL19210.1	cobB-2	SAMN05660976_01933	SAMN05660976_07014	Adenosylcobinamide kinase.	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.981
SEL19210.1	cobD	SAMN05660976_01933	SAMN05660976_07935	Adenosylcobinamide kinase.	Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.	0.993
SEN19618.1	SEL19210.1	SAMN05660976_07006	SAMN05660976_01933	precorrin-6Y C5,15-methyltransferase (decarboxylating).	Adenosylcobinamide kinase.	0.842
SEN19618.1	SEN19658.1	SAMN05660976_07006	SAMN05660976_07007	precorrin-6Y C5,15-methyltransferase (decarboxylating).	Precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family.	0.999
SEN19618.1	SEN19693.1	SAMN05660976_07006	SAMN05660976_07008	precorrin-6Y C5,15-methyltransferase (decarboxylating).	precorrin-6A reductase.	0.999
SEN19618.1	SEN19727.1	SAMN05660976_07006	SAMN05660976_07009	precorrin-6Y C5,15-methyltransferase (decarboxylating).	Precorrin-3 methyltransferase.	0.999
SEN19618.1	SEN19754.1	SAMN05660976_07006	SAMN05660976_07010	precorrin-6Y C5,15-methyltransferase (decarboxylating).	precorrin-8X methylmutase.	0.999
SEN19618.1	SEN19843.1	SAMN05660976_07006	SAMN05660976_07013	precorrin-6Y C5,15-methyltransferase (decarboxylating).	Cobaltochelatase CobN subunit.	0.946
SEN19618.1	SEN19925.1	SAMN05660976_07006	SAMN05660976_07015	precorrin-6Y C5,15-methyltransferase (decarboxylating).	cob(I)alamin adenosyltransferase.	0.822
SEN19618.1	SEN19949.1	SAMN05660976_07006	SAMN05660976_07016	precorrin-6Y C5,15-methyltransferase (decarboxylating).	Protoporphyrin IX magnesium-chelatase.	0.773
SEN19618.1	cobB-2	SAMN05660976_07006	SAMN05660976_07014	precorrin-6Y C5,15-methyltransferase (decarboxylating).	Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.	0.899
SEN19618.1	cobD	SAMN05660976_07006	SAMN05660976_07935	precorrin-6Y C5,15-methyltransferase (decarboxylating).	Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.	0.905

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Network Stats

number of nodes:

6

number of edges:

13

average node degree:

4.33

avg. local clustering coefficient:

0.822

expected number of edges:

7

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000162

Tryptophan biosynthetic process

6 of 8

2.58

5.47

1.97e-11

GO:0009073

Aromatic amino acid family biosynthetic process

7 of 22

2.21

4.91

1.97e-11

GO:0008652

Cellular amino acid biosynthetic process

8 of 170

1.38

2.12

1.19e-08

GO:0006520

Cellular amino acid metabolic process

9 of 265

1.24

1.79

6.71e-09

GO:1901605

Alpha-amino acid metabolic process

7 of 191

1.27

1.63

1.03e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

6 of 143

1.33

1.38

0.00010

GO:0046820

4-amino-4-deoxychorismate synthase activity

2 of 2

2.71

1.14

0.0084

GO:0004834

Tryptophan synthase activity

2 of 3

2.53

1.14

0.0084

GO:0004048

Anthranilate phosphoribosyltransferase activity

2 of 2

2.71

1.14

0.0084

GO:0016835

Carbon-oxygen lyase activity

3 of 64

1.38

0.65

0.0401

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2286

Aromatic amino acid biosynthesis, and DAHP synthetase I/KDSA

10 of 19

2.43

8.78

3.27e-20

CL:2307

Tryptophan biosynthesis

6 of 6

2.71

6.06

2.08e-12

CL:2211

Mixed, incl. Amino-acid biosynthesis, and Vitamin B6 binding

11 of 94

1.78

4.87

1.82e-17

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

7 of 34

2.02

4.43

2.83e-11

map01230

Biosynthesis of amino acids

8 of 205

1.3

1.86

3.81e-08

map00790

Folate biosynthesis

3 of 56

1.44

0.98

0.0058

map01110

Biosynthesis of secondary metabolites

8 of 771

0.72

0.6

0.00067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1516

0.53

0.39

0.0053

GOCC:0005622

Intracellular

11 of 2067

0.43

0.34

0.0053

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0822

Tryptophan biosynthesis

7 of 8

2.65

7.17

6.53e-15

KW-0057

Aromatic amino acid biosynthesis

8 of 18

2.36

6.75

2.25e-15

KW-0028

Amino-acid biosynthesis

9 of 69

1.82

4.49

4.62e-14

KW-0456

Lyase

6 of 92

1.52

2.16

5.61e-07

KW-0315

Glutamine amidotransferase

2 of 14

1.86

0.91

0.0178

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04715

Anthranilate synthase component I, N terminal region

3 of 3

2.71

2.22

8.21e-05

PF00425

Chorismate binding enzyme

3 of 4

2.58

2.2

8.21e-05

PF00591

Glycosyl transferase family, a/b domain

2 of 3

2.53

1.13

0.0085

PF07722

Peptidase C26

2 of 5

2.31

1.01

0.0134

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019999

Anthranilate synthase component I-like

3 of 3

2.71

2.01

0.00021

IPR006805

Anthranilate synthase component I, N-terminal

3 of 3

2.71

2.01

0.00021

IPR015890

Chorismate-utilising enzyme, C-terminal

3 of 4

2.58

1.99

0.00021

IPR005801

ADC synthase

3 of 4

2.58

1.99

0.00021

IPR006221

Anthranilate synthase/para-aminobenzoate synthase like domain

2 of 2

2.71

1.16

0.0078

(more ...)

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