SEN20209.1 protein (Nonomuraea pusilla) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

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[Homology]

Score

SEN20209.1

Hypothetical protein. (91 aa)

Predicted Functional Partners:

SEN20164.1

0.957

SEN20133.1

0.938

SEN20245.1

0.773

SEN14688.1

0.546

SEK28774.1

0.494

SEK54841.1

0.486

SEL84468.1

0.475

SEL69223.1

0.457

SEM15209.1

0.454

SEK76211.1

0.426

Your Current Organism:

Nonomuraea pusilla

NCBI taxonomy Id: 46177
Other names: ATCC 27296, Actinomadura pusilla, BCRC 11619, CBS 262.72, CCRC 11619, CCRC:11619, CECT 3284, CIP 106954, DSM 43357, IFO 14684, IMET 9586, JCM 3144, KCTC 9278, Microtetraspora pusilla, N. pusilla, NBRC 14684, NCIMB 11116, NRRL B-16126, Nonomuria pusilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEK28774.1	SEM15209.1	SAMN05660976_00176	SAMN05660976_04308	Hypothetical protein.	Multiple sugar transport system substrate-binding protein.	0.496
SEK28774.1	SEN14688.1	SAMN05660976_00176	SAMN05660976_06920	Hypothetical protein.	CARDB protein.	0.594
SEK28774.1	SEN20209.1	SAMN05660976_00176	SAMN05660976_07023	Hypothetical protein.	Hypothetical protein.	0.494
SEK54841.1	SEN20209.1	SAMN05660976_00617	SAMN05660976_07023	Hypothetical protein.	Hypothetical protein.	0.486
SEK76211.1	SEN20209.1	SAMN05660976_01185	SAMN05660976_07023	Glucose/arabinose dehydrogenase, beta-propeller fold.	Hypothetical protein.	0.426
SEL69223.1	SEL84468.1	SAMN05660976_03109	SAMN05660976_03514	FtsX-like permease family protein.	Hypothetical protein.	0.487
SEL69223.1	SEN14688.1	SAMN05660976_03109	SAMN05660976_06920	FtsX-like permease family protein.	CARDB protein.	0.423
SEL69223.1	SEN20209.1	SAMN05660976_03109	SAMN05660976_07023	FtsX-like permease family protein.	Hypothetical protein.	0.457
SEL84468.1	SEL69223.1	SAMN05660976_03514	SAMN05660976_03109	Hypothetical protein.	FtsX-like permease family protein.	0.487
SEL84468.1	SEN20209.1	SAMN05660976_03514	SAMN05660976_07023	Hypothetical protein.	Hypothetical protein.	0.475
SEM15209.1	SEK28774.1	SAMN05660976_04308	SAMN05660976_00176	Multiple sugar transport system substrate-binding protein.	Hypothetical protein.	0.496
SEM15209.1	SEN20209.1	SAMN05660976_04308	SAMN05660976_07023	Multiple sugar transport system substrate-binding protein.	Hypothetical protein.	0.454
SEN14688.1	SEK28774.1	SAMN05660976_06920	SAMN05660976_00176	CARDB protein.	Hypothetical protein.	0.594
SEN14688.1	SEL69223.1	SAMN05660976_06920	SAMN05660976_03109	CARDB protein.	FtsX-like permease family protein.	0.423
SEN14688.1	SEN20209.1	SAMN05660976_06920	SAMN05660976_07023	CARDB protein.	Hypothetical protein.	0.546
SEN20133.1	SEN20164.1	SAMN05660976_07021	SAMN05660976_07022	Oxidoreductase molybdopterin binding domain-containing protein.	Ferredoxin-NADP reductase.	0.948
SEN20133.1	SEN20209.1	SAMN05660976_07021	SAMN05660976_07023	Oxidoreductase molybdopterin binding domain-containing protein.	Hypothetical protein.	0.938
SEN20133.1	SEN20245.1	SAMN05660976_07021	SAMN05660976_07024	Oxidoreductase molybdopterin binding domain-containing protein.	Hypothetical protein.	0.773
SEN20164.1	SEN20133.1	SAMN05660976_07022	SAMN05660976_07021	Ferredoxin-NADP reductase.	Oxidoreductase molybdopterin binding domain-containing protein.	0.948
SEN20164.1	SEN20209.1	SAMN05660976_07022	SAMN05660976_07023	Ferredoxin-NADP reductase.	Hypothetical protein.	0.957

page 1 of 2

Network Stats

number of nodes:

6

number of edges:

13

average node degree:

4.33

avg. local clustering coefficient:

0.9

expected number of edges:

5

PPI enrichment p-value:

0.00196

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

8 of 46

2.54

7.32

1.05e-15

GO:0006790

Sulfur compound metabolic process

9 of 261

1.84

4.24

1.24e-12

GO:0043603

Cellular amide metabolic process

9 of 654

1.44

2.38

2.12e-09

GO:0009083

Branched-chain amino acid catabolic process

2 of 18

2.35

0.84

0.0292

GO:1901564

Organonitrogen compound metabolic process

11 of 4887

0.65

0.57

9.27e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004364

Glutathione transferase activity

6 of 17

2.85

6.39

8.04e-13

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

3 of 9

2.82

2.58

1.83e-05

GO:0003863

3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity

2 of 2

3.3

1.76

0.00067

GO:0015038

Glutathione disulfide oxidoreductase activity

2 of 4

3.0

1.6

0.0013

GO:0016491

Oxidoreductase activity

5 of 855

1.07

0.7

0.0116

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005947

Mitochondrial alpha-ketoglutarate dehydrogenase complex

2 of 5

2.9

1.23

0.0060

GO:1990204

Oxidoreductase complex

3 of 98

1.79

1.02

0.0095

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6169

Glutathione S-transferase, C-terminal, and Glutathione disulfide oxidoreductase activity

7 of 12

3.07

8.43

1.67e-16

CL:6164

Glutathione metabolism

8 of 47

2.53

7.5

3.67e-16

CL:6170

Glutathione S-transferase, N-terminal domain, and Glutathione S-transferase Theta, N-terminal

5 of 7

3.15

6.07

7.01e-12

CL:3842

Dihydrolipoyl dehydrogenase complex, and Pyruvate dehydrogenase complex

3 of 15

2.6

2.31

5.29e-05

CL:6183

Glutathione S-transferase, C-terminal domain, and Epoxide hydrolase

2 of 5

2.9

1.47

0.0022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

kmr00480

Glutathione metabolism

8 of 60

2.42

7.39

1.52e-16

kmr00982

Drug metabolism - cytochrome P450

6 of 33

2.56

6.08

8.07e-13

kmr00980

Metabolism of xenobiotics by cytochrome P450

6 of 39

2.49

5.88

1.34e-12

kmr00983

Drug metabolism - other enzymes

6 of 59

2.31

5.21

1.02e-11

kmr01100

Metabolic pathways

10 of 1588

1.1

1.49

1.41e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-156590

Glutathione conjugation

5 of 37

2.43

3.98

1.54e-08

MAP-156580

Phase II - Conjugation of compounds

5 of 89

2.05

2.97

4.91e-07

MAP-389661

Glyoxylate metabolism and glycine degradation

3 of 37

2.21

1.83

0.00031

MAP-211859

Biological oxidations

5 of 246

1.61

1.79

4.58e-05

MAP-9748784

Drug ADME

3 of 138

1.64

0.94

0.0115

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005947

Mitochondrial alpha-ketoglutarate dehydrogenase complex

2 of 4

3.0

1.27

0.0052

GOCC:1990204

Oxidoreductase complex

3 of 105

1.76

1.07

0.0071

GOCC:0005759

Mitochondrial matrix

3 of 193

1.49

0.77

0.0239

GOCC:0098798

Mitochondrial protein complex

3 of 226

1.42

0.7

0.0331

GOCC:0005737

Cytoplasm

10 of 6235

0.5

0.37

0.0087

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0786

Thiamine pyrophosphate

2 of 6

2.82

1.48

0.0021

KW-0560

Oxidoreductase

3 of 237

1.4

0.69

0.0336

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02798

Glutathione S-transferase, N-terminal domain

5 of 10

3.0

5.47

7.45e-11

PF00043

Glutathione S-transferase, C-terminal domain

4 of 7

3.06

4.31

1.28e-08

PF14497

Glutathione S-transferase, C-terminal domain

2 of 6

2.82

1.35

0.0036

PF02780

Transketolase, C-terminal domain

2 of 5

2.9

1.35

0.0036

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004045

Glutathione S-transferase, N-terminal

6 of 20

2.78

5.94

4.91e-12

IPR010987

Glutathione S-transferase, C-terminal-like

6 of 23

2.72

5.89

5.06e-12

IPR040079

Glutathione transferase family

6 of 25

2.68

5.84

5.22e-12

IPR036282

Glutathione S-transferase, C-terminal domain superfamily

6 of 34

2.55

5.43

2.04e-11

IPR004046

Glutathione S-transferase, C-terminal

5 of 13

2.88

5.29

1.34e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

2 of 8

2.7

1.15

0.0080

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