SEN20316.1 protein (Nonomuraea pusilla) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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Score

SEN20316.1

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain. (420 aa)

Predicted Functional Partners:

SEL81283.1

0.658

SEK57810.1

0.649

SEM86148.1

0.630

SEK40656.1

0.622

SEN20276.1

0.557

SEM95930.1

0.543

SEN48978.1

0.543

SEK69672.1

0.481

SEN03741.1

0.463

SEK60190.1

0.446

Your Current Organism:

Nonomuraea pusilla

NCBI taxonomy Id: 46177
Other names: ATCC 27296, Actinomadura pusilla, BCRC 11619, CBS 262.72, CCRC 11619, CCRC:11619, CECT 3284, CIP 106954, DSM 43357, IFO 14684, IMET 9586, JCM 3144, KCTC 9278, Microtetraspora pusilla, N. pusilla, NBRC 14684, NCIMB 11116, NRRL B-16126, Nonomuria pusilla

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEK40656.1	SEK57810.1	SAMN05660976_00471	SAMN05660976_00698	GntR family transcriptional regulator / MocR family aminotransferase.	Amino acid adenylation domain-containing protein.	0.649
SEK40656.1	SEK60190.1	SAMN05660976_00471	SAMN05660976_00760	GntR family transcriptional regulator / MocR family aminotransferase.	Thioesterase domain-containing protein.	0.446
SEK40656.1	SEL81283.1	SAMN05660976_00471	SAMN05660976_03397	GntR family transcriptional regulator / MocR family aminotransferase.	Anthranilate synthase, component I.	0.658
SEK40656.1	SEM86148.1	SAMN05660976_00471	SAMN05660976_06196	GntR family transcriptional regulator / MocR family aminotransferase.	2-oxoglutarate dehydrogenase E1 component.	0.630
SEK40656.1	SEM95930.1	SAMN05660976_00471	SAMN05660976_06471	GntR family transcriptional regulator / MocR family aminotransferase.	Amino acid adenylation domain-containing protein.	0.543
SEK40656.1	SEN03741.1	SAMN05660976_00471	SAMN05660976_06651	GntR family transcriptional regulator / MocR family aminotransferase.	Formate dehydrogenase iron-sulfur subunit.	0.463
SEK40656.1	SEN20316.1	SAMN05660976_00471	SAMN05660976_07026	GntR family transcriptional regulator / MocR family aminotransferase.	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain.	0.622
SEK40656.1	SEN48978.1	SAMN05660976_00471	SAMN05660976_07692	GntR family transcriptional regulator / MocR family aminotransferase.	Phosphopantetheine attachment site.	0.543
SEK57810.1	SEK40656.1	SAMN05660976_00698	SAMN05660976_00471	Amino acid adenylation domain-containing protein.	GntR family transcriptional regulator / MocR family aminotransferase.	0.649
SEK57810.1	SEK60190.1	SAMN05660976_00698	SAMN05660976_00760	Amino acid adenylation domain-containing protein.	Thioesterase domain-containing protein.	0.999
SEK57810.1	SEL81283.1	SAMN05660976_00698	SAMN05660976_03397	Amino acid adenylation domain-containing protein.	Anthranilate synthase, component I.	0.993
SEK57810.1	SEM86148.1	SAMN05660976_00698	SAMN05660976_06196	Amino acid adenylation domain-containing protein.	2-oxoglutarate dehydrogenase E1 component.	0.751
SEK57810.1	SEM95930.1	SAMN05660976_00698	SAMN05660976_06471	Amino acid adenylation domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999
SEK57810.1	SEN03741.1	SAMN05660976_00698	SAMN05660976_06651	Amino acid adenylation domain-containing protein.	Formate dehydrogenase iron-sulfur subunit.	0.961
SEK57810.1	SEN20316.1	SAMN05660976_00698	SAMN05660976_07026	Amino acid adenylation domain-containing protein.	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain.	0.649
SEK57810.1	SEN48978.1	SAMN05660976_00698	SAMN05660976_07692	Amino acid adenylation domain-containing protein.	Phosphopantetheine attachment site.	0.999
SEK60190.1	SEK40656.1	SAMN05660976_00760	SAMN05660976_00471	Thioesterase domain-containing protein.	GntR family transcriptional regulator / MocR family aminotransferase.	0.446
SEK60190.1	SEK57810.1	SAMN05660976_00760	SAMN05660976_00698	Thioesterase domain-containing protein.	Amino acid adenylation domain-containing protein.	0.999
SEK60190.1	SEL81283.1	SAMN05660976_00760	SAMN05660976_03397	Thioesterase domain-containing protein.	Anthranilate synthase, component I.	0.859
SEK60190.1	SEM86148.1	SAMN05660976_00760	SAMN05660976_06196	Thioesterase domain-containing protein.	2-oxoglutarate dehydrogenase E1 component.	0.779

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.916

expected number of edges:

29

PPI enrichment p-value:

0.0016

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006544

Glycine metabolic process

4 of 8

2.2

2.29

3.30e-05

GO:0019464

Glycine decarboxylation via glycine cleavage system

3 of 4

2.37

1.76

0.00051

GO:0006189

De novo IMP biosynthetic process

3 of 14

1.83

1.39

0.0015

GO:0035999

Tetrahydrofolate interconversion

2 of 3

2.32

1.31

0.0037

GO:0009156

Ribonucleoside monophosphate biosynthetic process

4 of 37

1.53

1.29

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

4 of 8

2.2

2.41

1.84e-05

GO:0016741

Transferase activity, transferring one-carbon groups

5 of 61

1.41

1.36

0.00031

GO:0019238

Cyclohydrolase activity

2 of 5

2.1

0.73

0.0440

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005960

Glycine cleavage complex

2 of 3

2.32

1.22

0.0055

GO:0005829

Cytosol

7 of 303

0.86

0.71

0.0012

GO:0005737

Cytoplasm

9 of 1173

0.38

0.26

0.0472

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31410034

(2019) Staphyloxanthin: a potential target for antivirulence therapy.

3 of 10

1.98

1.56

0.00079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1866

Glycine catabolic process

4 of 5

2.4

2.76

5.29e-06

CL:839

De novo IMP biosynthetic process

3 of 8

2.07

1.61

0.00075

CL:834

Nucleoside monophosphate biosynthetic process, and Pyrimidine metabolism

4 of 57

1.35

0.99

0.0040

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00670

One carbon pool by folate

5 of 17

1.97

2.95

3.19e-07

map00260

Glycine, serine and threonine metabolism

4 of 46

1.44

1.37

0.00033

map00630

Glyoxylate and dicarboxylate metabolism

4 of 49

1.41

1.35

0.00033

map01200

Carbon metabolism

6 of 114

1.22

1.33

3.39e-05

map01110

Biosynthesis of secondary metabolites

8 of 436

0.76

0.66

0.00029

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005960

Glycine cleavage complex

2 of 3

2.32

0.88

0.0239

GOCC:0005737

Cytoplasm

9 of 946

0.48

0.31

0.0352

GOCC:0005622

Intracellular

10 of 1285

0.39

0.28

0.0352

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

4 of 17

1.87

1.96

6.97e-05

KW-0554

One-carbon metabolism

2 of 5

2.1

0.9

0.0210

KW-0511

Multifunctional enzyme

2 of 10

1.8

0.71

0.0436

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