AMSG_02908 protein (Thecamonas trahens) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AMSG_02908

Ubiquitin carboxyl-terminal hydrolase. (713 aa)

Predicted Functional Partners:

AMSG_07946

0.743

AMSG_12202

0.743

AMSG_03966

0.704

AMSG_10491

0.704

AMSG_08067

0.698

AMSG_11130

0.694

AMSG_00122

0.627

AMSG_02219

0.626

AMSG_12328

0.624

AMSG_09964

0.624

Your Current Organism:

Thecamonas trahens

NCBI taxonomy Id: 461836
Other names: Amastigomonas sp. ATCC 50062, T. trahens ATCC 50062, Thecamonas trahens ATCC 50062

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMSG_00122	AMSG_02219	A0A0L0D0V2	A0A0L0DVJ7	NEDD8 protein.	Uncharacterized protein.	0.819
AMSG_00122	AMSG_02908	A0A0L0D0V2	A0A0L0D2M3	NEDD8 protein.	Ubiquitin carboxyl-terminal hydrolase.	0.627
AMSG_00122	AMSG_03966	A0A0L0D0V2	A0A0L0D5V7	NEDD8 protein.	Uncharacterized protein.	0.676
AMSG_00122	AMSG_07946	A0A0L0D0V2	A0A0L0DHK5	NEDD8 protein.	Ubiquitin C.	0.737
AMSG_00122	AMSG_08067	A0A0L0D0V2	A0A0L0DJC2	NEDD8 protein.	Ubiquitin/ribosomal protein S27 fusion protein.	0.945
AMSG_00122	AMSG_10491	A0A0L0D0V2	A0A0L0DSQ7	NEDD8 protein.	SH3 domain-containing protein.	0.676
AMSG_00122	AMSG_11130	A0A0L0D0V2	A0A0L0DU02	NEDD8 protein.	TKL protein kinase.	0.560
AMSG_00122	AMSG_12202	A0A0L0D0V2	A0A0L0DLX6	NEDD8 protein.	Uncharacterized protein.	0.737
AMSG_02219	AMSG_00122	A0A0L0DVJ7	A0A0L0D0V2	Uncharacterized protein.	NEDD8 protein.	0.819
AMSG_02219	AMSG_02908	A0A0L0DVJ7	A0A0L0D2M3	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.626
AMSG_02219	AMSG_07946	A0A0L0DVJ7	A0A0L0DHK5	Uncharacterized protein.	Ubiquitin C.	0.943
AMSG_02219	AMSG_08067	A0A0L0DVJ7	A0A0L0DJC2	Uncharacterized protein.	Ubiquitin/ribosomal protein S27 fusion protein.	0.971
AMSG_02219	AMSG_09964	A0A0L0DVJ7	A0A0L0DRX0	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.804
AMSG_02219	AMSG_12202	A0A0L0DVJ7	A0A0L0DLX6	Uncharacterized protein.	Uncharacterized protein.	0.943
AMSG_02219	AMSG_12328	A0A0L0DVJ7	A0A0L0DQ81	Uncharacterized protein.	Uncharacterized protein.	0.804
AMSG_02908	AMSG_00122	A0A0L0D2M3	A0A0L0D0V2	Ubiquitin carboxyl-terminal hydrolase.	NEDD8 protein.	0.627
AMSG_02908	AMSG_02219	A0A0L0D2M3	A0A0L0DVJ7	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.626
AMSG_02908	AMSG_03966	A0A0L0D2M3	A0A0L0D5V7	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.704
AMSG_02908	AMSG_07946	A0A0L0D2M3	A0A0L0DHK5	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin C.	0.743
AMSG_02908	AMSG_08067	A0A0L0D2M3	A0A0L0DJC2	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin/ribosomal protein S27 fusion protein.	0.698

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.846

expected number of edges:

16

PPI enrichment p-value:

1.71e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042537

Benzene-containing compound metabolic process

8 of 12

2.82

8.69

1.34e-17

GO:0006569

Tryptophan catabolic process

7 of 7

2.99

8.13

4.93e-16

GO:0034354

De novo NAD biosynthetic process from tryptophan

7 of 9

2.88

8.02

4.93e-16

GO:0043420

Anthranilate metabolic process

5 of 5

2.99

5.9

1.09e-11

GO:0019805

Quinolinate biosynthetic process

5 of 5

2.99

5.9

1.09e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004502

Kynurenine 3-monooxygenase activity

3 of 3

2.99

2.56

2.21e-05

GO:0016702

Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

3 of 12

2.39

2.0

0.00017

GO:0033754

Indoleamine 2,3-dioxygenase activity

2 of 2

2.99

1.6

0.0013

GO:0003882

CDP-diacylglycerol-serine O-phosphatidyltransferase activity

2 of 3

2.82

1.55

0.0015

GO:0071949

FAD binding

3 of 37

1.9

1.44

0.0013

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005741

Mitochondrial outer membrane

3 of 49

1.78

0.97

0.0123

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9771

Mixed, incl. Lipid biosynthetic process, and Tryptophan catabolism

10 of 172

1.76

4.28

2.15e-14

CL:9973

Amine catabolic process

4 of 5

2.9

4.11

2.57e-08

CL:9773

Mixed, incl. Steroid biosynthetic process, and Tryptophan catabolism

8 of 108

1.86

4.06

1.55e-11

CL:10041

Phosphatidylserine metabolic process, and Synthesis of CL

2 of 7

2.45

1.13

0.0085

CL:9779

Steroid biosynthetic process, and Tryptophan catabolism

3 of 60

1.69

1.02

0.0085

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00380

Tryptophan metabolism

8 of 42

2.27

6.48

2.63e-15

map01100

Metabolic pathways

11 of 1981

0.74

0.73

5.59e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71240

Tryptophan catabolism

11 of 24

2.65

11.89

6.26e-26

MAP-71291

Metabolism of amino acids and derivatives

11 of 236

1.66

4.1

3.13e-16

MAP-1430728

Metabolism

11 of 1327

0.91

1.04

2.96e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005741

Mitochondrial outer membrane

3 of 64

1.66

0.89

0.0161

GOCC:0005737

Cytoplasm

11 of 2575

0.62

0.54

0.00013

GOCC:0005739

Mitochondrion

5 of 623

0.9

0.49

0.0398

GOCC:0031090

Organelle membrane

5 of 695

0.85

0.46

0.0473

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0662

Pyridine nucleotide biosynthesis

3 of 5

2.77

2.88

4.80e-06

KW-0223

Dioxygenase

3 of 12

2.39

2.41

2.59e-05

KW-0560

Oxidoreductase

6 of 145

1.61

2.31

6.39e-07

KW-1000

Mitochondrion outer membrane

2 of 5

2.6

1.67

0.00087

KW-0503

Monooxygenase

3 of 37

1.9

1.66

0.00042

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01494

FAD binding domain

3 of 4

2.87

2.49

2.85e-05

PF01231

Indoleamine 2,3-dioxygenase

2 of 3

2.82

1.27

0.0049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002938

FAD-binding domain

3 of 4

2.87

2.24

8.17e-05

IPR037217

Tryptophan/Indoleamine 2,3-dioxygenase-like

2 of 3

2.82

1.15

0.0084

IPR027545

Kynurenine 3-monooxygenase

2 of 2

2.99

1.15

0.0084

IPR000898

Indoleamine 2,3-dioxygenase

2 of 3

2.82

1.15

0.0084

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 34

1.94

1.07

0.0084

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