AMSG_03884 protein (Thecamonas trahens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

AMSG_03884

Cell division cycle 16. (612 aa)

Predicted Functional Partners:

AMSG_03469

0.999

AMSG_05595

0.999

AMSG_06230

0.999

AMSG_11102

0.999

AMSG_10992

0.999

AMSG_03842

0.993

AMSG_02991

0.991

AMSG_09792

0.990

AMSG_01312

0.987

AMSG_00539

0.980

Your Current Organism:

Thecamonas trahens

NCBI taxonomy Id: 461836
Other names: Amastigomonas sp. ATCC 50062, T. trahens ATCC 50062, Thecamonas trahens ATCC 50062

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMSG_00539	AMSG_01312	A0A0L0D8Q5	A0A0L0DMS6	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	BUB protein kinase.	0.626
AMSG_00539	AMSG_02991	A0A0L0D8Q5	A0A0L0D2Y5	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	TPR_REGION domain-containing protein.	0.934
AMSG_00539	AMSG_03469	A0A0L0D8Q5	A0A0L0D3Y9	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	ANAPC5 domain-containing protein.	0.979
AMSG_00539	AMSG_03842	A0A0L0D8Q5	A0A0L0D7X5	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family.	0.971
AMSG_00539	AMSG_03884	A0A0L0D8Q5	A0A0L0D5N3	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	Cell division cycle 16.	0.980
AMSG_00539	AMSG_05595	A0A0L0D8Q5	A0A0L0DB60	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	WD_REPEATS_REGION domain-containing protein.	0.984
AMSG_00539	AMSG_06230	A0A0L0D8Q5	A0A0L0DCG0	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	TPR_REGION domain-containing protein.	0.999
AMSG_00539	AMSG_09792	A0A0L0D8Q5	A0A0L0DQY0	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	Mitotic spindle assembly checkpoint protein MAD2A.	0.648
AMSG_00539	AMSG_10992	A0A0L0D8Q5	A0A0L0DSY7	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.993
AMSG_00539	AMSG_11102	A0A0L0D8Q5	A0A0L0DSW2	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	Cell division cycle protein 23.	0.991
AMSG_01312	AMSG_00539	A0A0L0DMS6	A0A0L0D8Q5	BUB protein kinase.	Ubiquitin carrier protein; Belongs to the ubiquitin-conjugating enzyme family.	0.626
AMSG_01312	AMSG_02991	A0A0L0DMS6	A0A0L0D2Y5	BUB protein kinase.	TPR_REGION domain-containing protein.	0.964
AMSG_01312	AMSG_03469	A0A0L0DMS6	A0A0L0D3Y9	BUB protein kinase.	ANAPC5 domain-containing protein.	0.980
AMSG_01312	AMSG_03842	A0A0L0DMS6	A0A0L0D7X5	BUB protein kinase.	Ubiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family.	0.887
AMSG_01312	AMSG_03884	A0A0L0DMS6	A0A0L0D5N3	BUB protein kinase.	Cell division cycle 16.	0.987
AMSG_01312	AMSG_05595	A0A0L0DMS6	A0A0L0DB60	BUB protein kinase.	WD_REPEATS_REGION domain-containing protein.	0.985
AMSG_01312	AMSG_06230	A0A0L0DMS6	A0A0L0DCG0	BUB protein kinase.	TPR_REGION domain-containing protein.	0.992
AMSG_01312	AMSG_09792	A0A0L0DMS6	A0A0L0DQY0	BUB protein kinase.	Mitotic spindle assembly checkpoint protein MAD2A.	0.999
AMSG_01312	AMSG_10992	A0A0L0DMS6	A0A0L0DSY7	BUB protein kinase.	Anaphase-promoting complex subunit 2; Belongs to the cullin family.	0.980
AMSG_01312	AMSG_11102	A0A0L0DMS6	A0A0L0DSW2	BUB protein kinase.	Cell division cycle protein 23.	0.991

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.842

expected number of edges:

10

PPI enrichment p-value:

5.32e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016491

Oxidoreductase activity

7 of 284

0.88

0.65

0.0044

GO:0051536

Iron-sulfur cluster binding

6 of 221

0.92

0.64

0.0083

GO:0051539

4 iron, 4 sulfur cluster binding

4 of 107

1.06

0.55

0.0429

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3908

Sulfur metabolism, and Nitrate reductase complex

8 of 12

2.31

6.21

3.07e-14

CL:3906

Mixed, incl. Sulfur metabolism, and Sulfite exporter TauE/SafE

9 of 28

2.0

5.22

3.07e-14

CL:3910

Sulfur metabolism

5 of 5

2.49

4.39

2.59e-09

CL:3785

Mixed, incl. Cysteine-rich domain, and Sulfur metabolism

10 of 93

1.52

3.07

8.48e-13

CL:3921

Nitrite and sulphite reductase 4Fe-4S domain, and Nitrate reductase complex

2 of 5

2.09

0.97

0.0152

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dku00920

Sulfur metabolism

9 of 16

2.24

6.92

6.64e-17

dku01120

Microbial metabolism in diverse environments

9 of 239

1.07

1.31

1.21e-07

dku00633

Nitrotoluene degradation

2 of 8

1.89

1.02

0.0106

dku01100

Metabolic pathways

9 of 604

0.66

0.56

0.00024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03460

Nitrite/Sulfite reductase ferredoxin-like half domain

2 of 3

2.31

0.71

0.0497

PF01077

Nitrite and sulphite reductase 4Fe-4S domain

2 of 3

2.31

0.71

0.0497

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