AMSG_03917 protein (Thecamonas trahens) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

AMSG_03917

1-acylglycerol-3-phosphate acyltransferase. (363 aa)

Predicted Functional Partners:

AMSG_01883

0.729

AMSG_11216

0.710

AMSG_03218

0.638

AMSG_05180

0.635

AMSG_10399

0.629

AMSG_01634

0.626

AMSG_03439

0.623

AMSG_10349

0.622

AMSG_01222

0.616

AMSG_07180

0.614

Your Current Organism:

Thecamonas trahens

NCBI taxonomy Id: 461836
Other names: Amastigomonas sp. ATCC 50062, T. trahens ATCC 50062, Thecamonas trahens ATCC 50062

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMSG_01222	AMSG_01634	A0A0L0DMG1	A0A0L0DRA7	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Lipid phosphate phosphatase 2.	0.830
AMSG_01222	AMSG_01883	A0A0L0DMG1	A0A0L0DTG9	Glycerol-3-phosphate dehydrogenase [NAD(+)].	GP-PDE domain-containing protein.	0.666
AMSG_01222	AMSG_03218	A0A0L0DMG1	A0A0L0D648	Glycerol-3-phosphate dehydrogenase [NAD(+)].	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase.	0.441
AMSG_01222	AMSG_03439	A0A0L0DMG1	A0A0L0D432	Glycerol-3-phosphate dehydrogenase [NAD(+)].	LNS2 domain-containing protein.	0.772
AMSG_01222	AMSG_03917	A0A0L0DMG1	A0A0L0D6I8	Glycerol-3-phosphate dehydrogenase [NAD(+)].	1-acylglycerol-3-phosphate acyltransferase.	0.616
AMSG_01222	AMSG_05180	A0A0L0DMG1	A0A0L0DA21	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Glycerol-3-phosphate acyltransferase.	0.844
AMSG_01222	AMSG_07180	A0A0L0DMG1	A0A0L0DFI9	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	0.935
AMSG_01222	AMSG_10349	A0A0L0DMG1	A0A0L0DPW9	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.872
AMSG_01222	AMSG_10399	A0A0L0DMG1	A0A0L0DQJ7	Glycerol-3-phosphate dehydrogenase [NAD(+)].	PlsC domain-containing protein.	0.844
AMSG_01222	AMSG_11216	A0A0L0DMG1	A0A0L0DW84	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Mboat2 protein; Belongs to the membrane-bound acyltransferase family.	0.775
AMSG_01634	AMSG_01222	A0A0L0DRA7	A0A0L0DMG1	Lipid phosphate phosphatase 2.	Glycerol-3-phosphate dehydrogenase [NAD(+)].	0.830
AMSG_01634	AMSG_01883	A0A0L0DRA7	A0A0L0DTG9	Lipid phosphate phosphatase 2.	GP-PDE domain-containing protein.	0.866
AMSG_01634	AMSG_03218	A0A0L0DRA7	A0A0L0D648	Lipid phosphate phosphatase 2.	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase.	0.738
AMSG_01634	AMSG_03439	A0A0L0DRA7	A0A0L0D432	Lipid phosphate phosphatase 2.	LNS2 domain-containing protein.	0.886
AMSG_01634	AMSG_03917	A0A0L0DRA7	A0A0L0D6I8	Lipid phosphate phosphatase 2.	1-acylglycerol-3-phosphate acyltransferase.	0.626
AMSG_01634	AMSG_05180	A0A0L0DRA7	A0A0L0DA21	Lipid phosphate phosphatase 2.	Glycerol-3-phosphate acyltransferase.	0.665
AMSG_01634	AMSG_07180	A0A0L0DRA7	A0A0L0DFI9	Lipid phosphate phosphatase 2.	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	0.842
AMSG_01634	AMSG_10399	A0A0L0DRA7	A0A0L0DQJ7	Lipid phosphate phosphatase 2.	PlsC domain-containing protein.	0.775
AMSG_01634	AMSG_11216	A0A0L0DRA7	A0A0L0DW84	Lipid phosphate phosphatase 2.	Mboat2 protein; Belongs to the membrane-bound acyltransferase family.	0.846
AMSG_01883	AMSG_01222	A0A0L0DTG9	A0A0L0DMG1	GP-PDE domain-containing protein.	Glycerol-3-phosphate dehydrogenase [NAD(+)].	0.666

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.761

expected number of edges:

12

PPI enrichment p-value:

9.59e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018105

Peptidyl-serine phosphorylation

3 of 90

1.9

1.1

0.0072

GO:0071218

Cellular response to misfolded protein

2 of 19

2.4

0.99

0.0155

GO:0051247

Positive regulation of protein metabolic process

3 of 135

1.73

0.96

0.0118

GO:0006515

Protein quality control for misfolded or incompletely synthesized proteins

2 of 43

2.05

0.73

0.0434

GO:0045862

Positive regulation of proteolysis

2 of 57

1.93

0.71

0.0450

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004842

Ubiquitin-protein transferase activity

4 of 422

1.36

0.82

0.0137

GO:0061630

Ubiquitin protein ligase activity

3 of 225

1.51

0.74

0.0291

GO:0140096

Catalytic activity, acting on a protein

9 of 3324

0.81

0.69

0.00053

GO:0016740

Transferase activity

10 of 4634

0.71

0.6

0.00053

GO:0016301

Kinase activity

6 of 1874

0.89

0.56

0.0178

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005776

Autophagosome

2 of 22

2.34

0.79

0.0353

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13820

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin homologues

3 of 84

1.93

0.83

0.0263

CL:20418

Mixed, incl. MAP kinase activity, and Rho (Ras homology) subfamily of Ras-like small GTPases

2 of 21

2.36

0.82

0.0312

CL:35943

Autophagy - other

2 of 23

2.32

0.82

0.0317

CL:13925

Ubiquitin conjugating enzyme activity, and Lipid desaturase domain

2 of 27

2.25

0.78

0.0375

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005776

Autophagosome

2 of 17

2.45

0.81

0.0341

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045202

CHIP , U-box domain

2 of 2

3.38

1.25

0.0056

IPR045200

E3 ubiquitin-protein ligase CHIP

2 of 2

3.38

1.25

0.0056

IPR000433

Zinc finger, ZZ-type

2 of 8

2.78

1.03

0.0139

IPR043145

Zinc finger, ZZ-type superfamily

2 of 9

2.73

1.02

0.0139

IPR027370

Zinc finger, RING-type, eukaryotic

2 of 12

2.6

0.98

0.0168

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00028

Tetratricopeptide repeats

3 of 67

2.03

1.47

0.0014

SM00291

Zinc-binding domain, present in Dystrophin, CREB-binding protein.

2 of 15

2.51

1.25

0.0052

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