STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMSG_00725AAA_23 domain-containing protein. (1328 aa)    
Predicted Functional Partners:
AMSG_10648
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
  
 0.999
AMSG_02997
Uncharacterized protein.
    
 0.998
AMSG_00041
3'-5' exonuclease.
  
 0.994
AMSG_00980
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.994
AMSG_05061
JmjC domain-containing histone demethylation protein 3C.
    
  0.987
AMSG_07133
Serine-protein kinase ATM; Belongs to the PI3/PI4-kinase family.
   
 0.980
AMSG_06102
ATP-dependent DNA helicase 2 subunit 1.
   
 0.951
AMSG_01661
Atypical/PIKK/ATR protein kinase; Belongs to the PI3/PI4-kinase family.
   
 0.918
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
  
 0.899
AMSG_12400
DNA polymerase.
  
 0.849
Your Current Organism:
Thecamonas trahens
NCBI taxonomy Id: 461836
Other names: Amastigomonas sp. ATCC 50062, T. trahens ATCC 50062, Thecamonas trahens ATCC 50062
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.