AMSG_00941 protein (Thecamonas trahens) - STRING interaction network

Nodes:

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

AMSG_00941

Appr-1-p processing domain-containing protein. (562 aa)

Predicted Functional Partners:

AMSG_04941

0.567

AMSG_10584

0.567

AMSG_04325

0.548

AMSG_05893

0.548

AMSG_11021

0.548

AMSG_03159

0.503

AMSG_05095

0.503

AMSG_05640

0.503

AMSG_06720

0.503

AMSG_01260

0.503

Your Current Organism:

Thecamonas trahens

NCBI taxonomy Id: 461836
Other names: Amastigomonas sp. ATCC 50062, T. trahens ATCC 50062, Thecamonas trahens ATCC 50062

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMSG_00941	AMSG_01260	A0A0L0DID1	A0A0L0DMK4	Appr-1-p processing domain-containing protein.	Histone deacetylase 6.	0.503
AMSG_00941	AMSG_03159	A0A0L0DID1	A0A0L0D314	Appr-1-p processing domain-containing protein.	Class II RPD3 type histone deacetylase.	0.503
AMSG_00941	AMSG_04325	A0A0L0DID1	A0A0L0D7D5	Appr-1-p processing domain-containing protein.	Apoptosis-inducing factor 2.	0.548
AMSG_00941	AMSG_04941	A0A0L0DID1	A0A0L0D819	Appr-1-p processing domain-containing protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.567
AMSG_00941	AMSG_05095	A0A0L0DID1	A0A0L0DA71	Appr-1-p processing domain-containing protein.	Deacetylase.	0.503
AMSG_00941	AMSG_05640	A0A0L0DID1	A0A0L0DBJ7	Appr-1-p processing domain-containing protein.	GGACT domain-containing protein.	0.503
AMSG_00941	AMSG_05893	A0A0L0DID1	A0A0L0DDF3	Appr-1-p processing domain-containing protein.	FAD-dependent pyridine nucleotide-disulfide oxidoreductase.	0.548
AMSG_00941	AMSG_06720	A0A0L0DID1	A0A0L0DF95	Appr-1-p processing domain-containing protein.	Coiled-coil domain containing 96.	0.503
AMSG_00941	AMSG_10584	A0A0L0DID1	A0A0L0DRP2	Appr-1-p processing domain-containing protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.567
AMSG_00941	AMSG_11021	A0A0L0DID1	A0A0L0DSW5	Appr-1-p processing domain-containing protein.	Pyridine nucleotide-disulfide oxidoreductase.	0.548
AMSG_01260	AMSG_00941	A0A0L0DMK4	A0A0L0DID1	Histone deacetylase 6.	Appr-1-p processing domain-containing protein.	0.503
AMSG_01260	AMSG_04941	A0A0L0DMK4	A0A0L0D819	Histone deacetylase 6.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.638
AMSG_01260	AMSG_10584	A0A0L0DMK4	A0A0L0DRP2	Histone deacetylase 6.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.646
AMSG_03159	AMSG_00941	A0A0L0D314	A0A0L0DID1	Class II RPD3 type histone deacetylase.	Appr-1-p processing domain-containing protein.	0.503
AMSG_03159	AMSG_04941	A0A0L0D314	A0A0L0D819	Class II RPD3 type histone deacetylase.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.640
AMSG_03159	AMSG_10584	A0A0L0D314	A0A0L0DRP2	Class II RPD3 type histone deacetylase.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.649
AMSG_04325	AMSG_00941	A0A0L0D7D5	A0A0L0DID1	Apoptosis-inducing factor 2.	Appr-1-p processing domain-containing protein.	0.548
AMSG_04941	AMSG_00941	A0A0L0D819	A0A0L0DID1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Appr-1-p processing domain-containing protein.	0.567
AMSG_04941	AMSG_01260	A0A0L0D819	A0A0L0DMK4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone deacetylase 6.	0.638
AMSG_04941	AMSG_03159	A0A0L0D819	A0A0L0D314	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Class II RPD3 type histone deacetylase.	0.640

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006906

Vesicle fusion

7 of 29

2.23

5.08

9.03e-12

GO:0048284

Organelle fusion

8 of 47

2.08

4.94

2.04e-12

GO:0016050

Vesicle organization

8 of 50

2.05

4.86

2.04e-12

GO:0048278

Vesicle docking

4 of 18

2.19

2.75

3.13e-06

GO:0048193

Golgi vesicle transport

7 of 133

1.57

2.44

6.94e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000149

SNARE binding

5 of 27

2.11

3.01

5.62e-07

GO:0005484

SNAP receptor activity

3 of 20

2.02

1.34

0.0026

GO:0030674

Protein-macromolecule adaptor activity

4 of 86

1.51

1.15

0.0026

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005768

Endosome

6 of 121

1.54

2.17

7.36e-07

GO:0000139

Golgi membrane

5 of 85

1.62

2.04

7.24e-06

GO:0005794

Golgi apparatus

7 of 200

1.39

1.91

5.25e-07

GO:0031201

SNARE complex

3 of 18

2.07

1.89

0.00018

GO:0010008

Endosome membrane

4 of 53

1.72

1.85

6.57e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6105

Intra-Golgi and retrograde Golgi-to-ER traffic, and Organelle fusion

9 of 101

1.8

4.09

1.22e-12

CL:6237

Mixed, incl. HOPS complex, and RAB geranylgeranylation

5 of 35

2.0

2.94

4.25e-07

CL:6238

Mixed, incl. HOPS complex, and Mon1-Ccz1 complex

4 of 19

2.17

2.64

5.09e-06

CL:6113

SNARE, and CDC48, domain 2

3 of 6

2.54

2.4

3.34e-05

CL:6109

Retrograde transport at the Trans-Golgi-Network, and SNAP receptor activity

4 of 30

1.97

2.23

2.20e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04138

Autophagy - yeast

5 of 91

1.59

1.9

1.67e-05

map04130

SNARE interactions in vesicular transport

3 of 23

1.96

1.77

0.00026

map04144

Endocytosis

5 of 147

1.38

1.46

8.31e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6811442

Intra-Golgi and retrograde Golgi-to-ER traffic

6 of 95

1.65

2.26

1.71e-06

MAP-6811440

Retrograde transport at the Trans-Golgi-Network

4 of 37

1.88

1.9

9.96e-05

MAP-6811438

Intra-Golgi traffic

3 of 21

2.0

1.57

0.00078

MAP-199991

Membrane Trafficking

6 of 244

1.24

1.25

0.00013

MAP-5653656

Vesicle-mediated transport

6 of 246

1.23

1.24

0.00013

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0012505

Endomembrane system

7 of 577

0.93

0.71

0.0032

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00995

Sec1 family

2 of 5

2.45

0.83

0.0310

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010989

SNARE

3 of 6

2.54

1.83

0.00041

IPR000727

Target SNARE coiled-coil homology domain

3 of 10

2.32

1.68

0.00070

IPR045242

Syntaxin

2 of 5

2.45

0.84

0.0296

IPR036045

Sec1-like superfamily

2 of 5

2.45

0.84

0.0296

IPR027482

Sec1-like, domain 2

2 of 5

2.45

0.84

0.0296

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00397

Helical region found in SNAREs

3 of 9

2.37

2.06

0.00013

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