AMSG_08298 protein (Thecamonas trahens) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AMSG_08298

Uncharacterized protein. (203 aa)

Predicted Functional Partners:

AMSG_03762

0.675

AMSG_04725

0.675

AMSG_00602

0.675

AMSG_10657

0.675

AMSG_09400

0.500

AMSG_03139

0.479

AMSG_03194

0.479

AMSG_04227

0.479

AMSG_04897

0.479

AMSG_04842

0.479

Your Current Organism:

Thecamonas trahens

NCBI taxonomy Id: 461836
Other names: Amastigomonas sp. ATCC 50062, T. trahens ATCC 50062, Thecamonas trahens ATCC 50062

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMSG_00602	AMSG_08298	A0A0L0DGH7	A0A0L0DJF0	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.675
AMSG_00602	AMSG_09400	A0A0L0DGH7	A0A0L0DNW8	Serine/threonine-protein phosphatase.	Serine/threonine-protein phosphatase.	0.406
AMSG_00602	AMSG_10657	A0A0L0DGH7	A0A0L0DSS8	Serine/threonine-protein phosphatase.	Serine/threonine-protein phosphatase.	0.630
AMSG_03139	AMSG_08298	A0A0L0D2Z4	A0A0L0DJF0	SER_THR_PHOSPHATASE domain-containing protein.	Uncharacterized protein.	0.479
AMSG_03194	AMSG_08298	A0A0L0D3Q6	A0A0L0DJF0	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.479
AMSG_03762	AMSG_08298	A0A0L0D4S5	A0A0L0DJF0	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Uncharacterized protein.	0.675
AMSG_04227	AMSG_08298	A0A0L0D6I4	A0A0L0DJF0	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.479
AMSG_04725	AMSG_08298	A0A0L0DA61	A0A0L0DJF0	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.675
AMSG_04842	AMSG_08298	A0A0L0DAR8	A0A0L0DJF0	Serine/threonine-protein phosphatase.	Uncharacterized protein.	0.479
AMSG_04897	AMSG_08298	A0A0L0D8P0	A0A0L0DJF0	Metallophos domain-containing protein.	Uncharacterized protein.	0.479
AMSG_08298	AMSG_00602	A0A0L0DJF0	A0A0L0DGH7	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.675
AMSG_08298	AMSG_03139	A0A0L0DJF0	A0A0L0D2Z4	Uncharacterized protein.	SER_THR_PHOSPHATASE domain-containing protein.	0.479
AMSG_08298	AMSG_03194	A0A0L0DJF0	A0A0L0D3Q6	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.479
AMSG_08298	AMSG_03762	A0A0L0DJF0	A0A0L0D4S5	Uncharacterized protein.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.675
AMSG_08298	AMSG_04227	A0A0L0DJF0	A0A0L0D6I4	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.479
AMSG_08298	AMSG_04725	A0A0L0DJF0	A0A0L0DA61	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.675
AMSG_08298	AMSG_04842	A0A0L0DJF0	A0A0L0DAR8	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.479
AMSG_08298	AMSG_04897	A0A0L0DJF0	A0A0L0D8P0	Uncharacterized protein.	Metallophos domain-containing protein.	0.479
AMSG_08298	AMSG_09400	A0A0L0DJF0	A0A0L0DNW8	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.500
AMSG_08298	AMSG_10657	A0A0L0DJF0	A0A0L0DSS8	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.675

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016570

Histone modification

6 of 89

1.91

3.1

6.62e-08

GO:0016573

Histone acetylation

4 of 33

2.16

2.75

2.85e-06

GO:0045893

Positive regulation of transcription, DNA-templated

7 of 165

1.71

2.74

6.62e-08

GO:0051123

RNA polymerase II preinitiation complex assembly

3 of 24

2.17

2.03

0.00011

GO:0016578

Histone deubiquitination

2 of 2

3.08

1.94

0.00031

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003713

Transcription coactivator activity

4 of 20

2.38

2.78

4.57e-06

GO:0003712

Transcription coregulator activity

5 of 81

1.87

2.41

4.57e-06

GO:0046982

Protein heterodimerization activity

3 of 34

2.02

1.41

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000124

SAGA complex

10 of 19

2.8

11.63

4.29e-24

GO:0046695

SLIK (SAGA-like) complex

3 of 5

2.86

3.2

1.28e-06

GO:0005669

Transcription factor TFIID complex

3 of 17

2.32

2.41

2.30e-05

GO:0043231

Intracellular membrane-bounded organelle

11 of 4898

0.43

0.36

0.00073

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3955

SAGA complex

8 of 17

2.75

8.53

1.66e-17

CL:3960

SAGA complex

6 of 11

2.81

6.68

1.83e-13

CL:3963

SAGA complex

4 of 6

2.9

4.29

1.15e-08

CL:4304

Transcription factor TFIID complex

3 of 10

2.56

2.48

2.35e-05

CL:4305

Transcription factor TFIID complex

2 of 5

2.68

1.49

0.0019

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03022

Basal transcription factors

3 of 72

1.7

1.14

0.0043

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689880

Ub-specific processing proteases

4 of 77

1.79

1.61

0.00040

MAP-5688426

Deubiquitination

4 of 114

1.62

1.37

0.00091

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

3 of 51

1.85

1.24

0.0033

MAP-75953

RNA Polymerase II Transcription Initiation

3 of 51

1.85

1.24

0.0033

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

3 of 51

1.85

1.24

0.0033

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070461

SAGA-type complex

6 of 15

2.68

6.08

1.73e-12

GOCC:0000124

SAGA complex

5 of 13

2.66

5.04

2.28e-10

GOCC:0005654

Nucleoplasm

10 of 287

1.62

3.52

3.17e-13

GOCC:1990234

Transferase complex

8 of 397

1.38

2.14

1.04e-08

GOCC:0071819

DUBm complex

2 of 3

2.9

1.9

0.00035

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

3 of 41

1.94

1.44

0.0014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009072

Histone-fold

3 of 29

2.09

1.16

0.0064

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