STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (435 aa)    
Predicted Functional Partners:
SEK79102.1
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase.
 
 
 0.999
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.998
thiG
Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 0.995
SEK79209.1
2-iminoacetate synthase.
 
  
 0.984
SEK79129.1
Sulfur carrier protein.
  
  
 0.939
purM
Phosphoribosylformylglycinamidine cyclo-ligase.
     
 0.906
SEK17557.1
2-iminoacetate synthase.
 
  
 0.867
thiF
Thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily.
 
  
 0.836
thiS
Sulfur carrier protein.
  
  
 0.790
SEK79163.1
Sulfur carrier protein ThiS adenylyltransferase.
       0.741
Your Current Organism:
Pseudobutyrivibrio ruminis
NCBI taxonomy Id: 46206
Other names: DSM 9787, P. ruminis, strain A12-1
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.