CUP57667.1 protein (Parabacteroides merdae) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CUP57667.1

CO dehydrogenase maturation factor. (254 aa)

Predicted Functional Partners:

CUO44962.1

0.780

CUP58217.1

0.780

CUO45000.1

0.779

traJ

0.779

CUO44888.1

0.778

CUP57706.1

0.778

CUP57778.1

0.778

traM

0.777

CUP58423.1

0.776

CUO45147.1

0.775

Your Current Organism:

Parabacteroides merdae

NCBI taxonomy Id: 46503
Other names: ATCC 43184, Bacteroides merdae, CCUG 38734, CIP 104202, JCM 9497, NCTC 13052, P. merdae, VPI T4-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUO44888.1	CUO44962.1	ERS852463_00238	ERS852463_00240	Uncharacterised protein.	Uncharacterised protein.	0.945
CUO44888.1	CUO45000.1	ERS852463_00238	ERS852463_00241	Uncharacterised protein.	Bacteroides conjugative transposon TraJ protein.	0.932
CUO44888.1	CUO45147.1	ERS852463_00238	ERS852463_00245	Uncharacterised protein.	Bacteroides conjugative transposon TraN protein.	0.899
CUO44888.1	CUP57667.1	ERS852463_00238	ERS852463_02879	Uncharacterised protein.	CO dehydrogenase maturation factor.	0.778
CUO44888.1	CUP58217.1	ERS852463_00238	ERS852463_02893	Uncharacterised protein.	Uncharacterised protein.	0.787
CUO44888.1	CUP58423.1	ERS852463_00238	ERS852463_02898	Uncharacterised protein.	Bacteroides conjugative transposon TraN protein.	0.784
CUO44888.1	traJ	ERS852463_00238	ERS852463_02894	Uncharacterised protein.	Bacteroides conjugative transposon TraJ protein.	0.788
CUO44888.1	traM	ERS852463_00238	ERS852463_02897	Uncharacterised protein.	Bacteroides conjugative transposon TraM protein.	0.785
CUO44962.1	CUO44888.1	ERS852463_00240	ERS852463_00238	Uncharacterised protein.	Uncharacterised protein.	0.945
CUO44962.1	CUO45000.1	ERS852463_00240	ERS852463_00241	Uncharacterised protein.	Bacteroides conjugative transposon TraJ protein.	0.936
CUO44962.1	CUO45147.1	ERS852463_00240	ERS852463_00245	Uncharacterised protein.	Bacteroides conjugative transposon TraN protein.	0.900
CUO44962.1	CUP57667.1	ERS852463_00240	ERS852463_02879	Uncharacterised protein.	CO dehydrogenase maturation factor.	0.780
CUO44962.1	CUP58423.1	ERS852463_00240	ERS852463_02898	Uncharacterised protein.	Bacteroides conjugative transposon TraN protein.	0.781
CUO44962.1	traJ	ERS852463_00240	ERS852463_02894	Uncharacterised protein.	Bacteroides conjugative transposon TraJ protein.	0.785
CUO44962.1	traM	ERS852463_00240	ERS852463_02897	Uncharacterised protein.	Bacteroides conjugative transposon TraM protein.	0.781
CUO45000.1	CUO44888.1	ERS852463_00241	ERS852463_00238	Bacteroides conjugative transposon TraJ protein.	Uncharacterised protein.	0.932
CUO45000.1	CUO44962.1	ERS852463_00241	ERS852463_00240	Bacteroides conjugative transposon TraJ protein.	Uncharacterised protein.	0.936
CUO45000.1	CUO45147.1	ERS852463_00241	ERS852463_00245	Bacteroides conjugative transposon TraJ protein.	Bacteroides conjugative transposon TraN protein.	0.910
CUO45000.1	CUP57667.1	ERS852463_00241	ERS852463_02879	Bacteroides conjugative transposon TraJ protein.	CO dehydrogenase maturation factor.	0.779
CUO45000.1	CUP58217.1	ERS852463_00241	ERS852463_02893	Bacteroides conjugative transposon TraJ protein.	Uncharacterised protein.	0.785

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.9

expected number of edges:

47

PPI enrichment p-value:

0.403

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008092

Cytoskeletal protein binding

3 of 175

1.55

0.71

0.0370

GO:0005515

Protein binding

6 of 1256

1.0

0.64

0.0151

GO:0005488

Binding

10 of 6755

0.49

0.33

0.0299

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005856

Cytoskeleton

4 of 286

1.47

0.99

0.0062

GO:0071944

Cell periphery

5 of 809

1.11

0.76

0.0086

GO:0005886

Plasma membrane

4 of 601

1.14

0.6

0.0365

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:534

CD28 dependent Vav1 pathway, and PB1 domain

2 of 6

2.84

1.03

0.0137

CL:484

Mixed, incl. Small GTPase mediated signal transduction, and RAC1 GTPase cycle

3 of 91

1.84

0.96

0.0137

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5626467

RHO GTPases activate IQGAPs

2 of 5

2.92

1.32

0.0041

MAP-389359

CD28 dependent Vav1 pathway

2 of 5

2.92

1.32

0.0041

MAP-5627123

RHO GTPases activate PAKs

2 of 11

2.58

1.31

0.0041

MAP-389356

CD28 co-stimulation

2 of 14

2.48

1.27

0.0046

MAP-9013424

RHOV GTPase cycle

2 of 17

2.39

1.25

0.0049

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003578

Small GTPase Rho

2 of 9

2.67

0.8

0.0363

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

2 of 7

2.78

1.42

0.0026

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