Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
clpCPutative ATP-dependent Clp protease ATP-binding subunit, ClpC-like; Belongs to the ClpA/ClpB family. (842 aa)    
Predicted Functional Partners:
dnaK
Putative chaperone protein, DnaK-like; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.917
htpG
Putative chaperone protein, HtpG-like.
  
 
 0.916
clpP_1
ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.869
KWR53594.1
Acid shock protein; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.812
clpP_2
ATP-dependent Clp protease proteolytic subunit; Belongs to the peptidase S14 family.
   
 
 0.784
groL
GroL-like chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 
 0.707
dnaJ_2
Putative chaperone protein, DnaJ-like.
  
 
 0.682
rssA_2
Putative NTE family protein, RssA-like.
   
 
 0.668
grpE
Putative heat shock protein, GrpE-like; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several [...]
  
 
 0.656
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.632
Your Current Organism:
Bacteroides stercoris
NCBI taxonomy Id: 46506
Other names: ATCC 43183, B. stercoris, CCUG 38733, CIP 104203, JCM 9496, NCTC 13053, VPI B5-21
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