AMN48263.1 protein (Steroidobacter denitrificans)

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

AMN48263.1

Hypothetical protein. (429 aa)

Predicted Functional Partners:

AMN46951.1

0.971

AMN47981.1

0.927

AMN47976.1

0.916

AMN46381.1

0.912

AMN47506.1

0.818

AMN47838.1

0.799

AMN47292.1

0.797

AMN47974.1

0.783

AMN48262.1

0.774

AMN47418.1

0.743

Your Current Organism:

Steroidobacter denitrificans

NCBI taxonomy Id: 465721
Other names: DSM 18526, JCM 14622, S. denitrificans, Steroidobacter denitrificans Fahrbach et al. 2008, gamma proteobacterium FS-2007, strain FS

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMN46381.1	AMN47292.1	ACG33_04515	ACG33_09335	Hypothetical protein.	Hypothetical protein.	0.967
AMN46381.1	AMN47418.1	ACG33_04515	ACG33_09980	Hypothetical protein.	Hypothetical protein.	0.803
AMN46381.1	AMN47506.1	ACG33_04515	ACG33_10430	Hypothetical protein.	Hypothetical protein.	0.574
AMN46381.1	AMN47838.1	ACG33_04515	ACG33_12160	Hypothetical protein.	Hypothetical protein.	0.566
AMN46381.1	AMN47974.1	ACG33_04515	ACG33_12875	Hypothetical protein.	Hypothetical protein.	0.925
AMN46381.1	AMN48263.1	ACG33_04515	ACG33_14380	Hypothetical protein.	Hypothetical protein.	0.912
AMN46951.1	AMN47292.1	ACG33_07540	ACG33_09335	Hypothetical protein.	Hypothetical protein.	0.976
AMN46951.1	AMN47418.1	ACG33_07540	ACG33_09980	Hypothetical protein.	Hypothetical protein.	0.756
AMN46951.1	AMN47506.1	ACG33_07540	ACG33_10430	Hypothetical protein.	Hypothetical protein.	0.469
AMN46951.1	AMN47838.1	ACG33_07540	ACG33_12160	Hypothetical protein.	Hypothetical protein.	0.453
AMN46951.1	AMN47974.1	ACG33_07540	ACG33_12875	Hypothetical protein.	Hypothetical protein.	0.938
AMN46951.1	AMN48263.1	ACG33_07540	ACG33_14380	Hypothetical protein.	Hypothetical protein.	0.971
AMN47292.1	AMN46381.1	ACG33_09335	ACG33_04515	Hypothetical protein.	Hypothetical protein.	0.967
AMN47292.1	AMN46951.1	ACG33_09335	ACG33_07540	Hypothetical protein.	Hypothetical protein.	0.976
AMN47292.1	AMN47418.1	ACG33_09335	ACG33_09980	Hypothetical protein.	Hypothetical protein.	0.890
AMN47292.1	AMN47506.1	ACG33_09335	ACG33_10430	Hypothetical protein.	Hypothetical protein.	0.894
AMN47292.1	AMN47838.1	ACG33_09335	ACG33_12160	Hypothetical protein.	Hypothetical protein.	0.868
AMN47292.1	AMN47974.1	ACG33_09335	ACG33_12875	Hypothetical protein.	Hypothetical protein.	0.913
AMN47292.1	AMN47976.1	ACG33_09335	ACG33_12885	Hypothetical protein.	Hypothetical protein.	0.949
AMN47292.1	AMN47981.1	ACG33_09335	ACG33_12910	Hypothetical protein.	Hypothetical protein.	0.958

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

20

PPI enrichment p-value:

8.9e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

5 of 23

2.29

3.8

2.05e-08

GO:0006364

rRNA processing

10 of 205

1.64

3.59

3.74e-13

GO:0042254

Ribosome biogenesis

11 of 267

1.57

3.44

2.58e-14

GO:0042273

Ribosomal large subunit biogenesis

6 of 64

1.92

3.32

1.82e-08

GO:0000466

Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

5 of 47

1.98

2.93

3.83e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

8 of 537

1.13

1.22

1.78e-05

GO:0043021

Ribonucleoprotein complex binding

3 of 39

1.84

1.13

0.0059

GO:0070180

Large ribosomal subunit rRNA binding

2 of 8

2.35

0.93

0.0193

GO:0005488

Binding

11 of 4312

0.36

0.26

0.0342

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

7 of 30

2.32

5.68

7.77e-13

GO:0030684

Preribosome

8 of 89

1.91

4.38

2.91e-12

GO:0005730

Nucleolus

10 of 232

1.59

3.35

5.86e-13

GO:1990904

Ribonucleoprotein complex

10 of 436

1.31

2.16

7.08e-11

GO:0005732

sno(s)RNA-containing ribonucleoprotein complex

2 of 24

1.87

0.92

0.0169

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4359

Preribosome, large subunit precursor, and Maturation of LSU-rRNA

7 of 30

2.32

5.55

1.64e-12

CL:4363

Preribosome, large subunit precursor, and Ribosomal protein L10

6 of 19

2.45

5.44

1.02e-11

CL:4368

Preribosome, large subunit precursor

4 of 5

2.86

4.26

1.24e-08

CL:4188

Nucleolus

9 of 149

1.73

3.84

1.72e-12

CL:4177

Ribosome biogenesis, and tRNA modification

10 of 198

1.66

3.68

2.64e-13

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

4 of 93

1.59

1.47

0.00041

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

6 of 132

1.61

2.15

2.74e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

6 of 136

1.6

2.13

2.74e-06

MAP-72312

rRNA processing

6 of 141

1.58

2.1

2.74e-06

MAP-8953854

Metabolism of RNA

8 of 553

1.11

1.28

3.44e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005730

Nucleolus

5 of 120

1.57

1.85

2.10e-05

GOCC:0031981

Nuclear lumen

9 of 510

1.2

1.58

1.38e-07

GOCC:0005732

Small nucleolar ribonucleoprotein complex

2 of 21

1.93

0.87

0.0217

GOCC:0005634

Nucleus

10 of 1299

0.84

0.85

3.04e-06

GOCC:1990904

Ribonucleoprotein complex

5 of 415

1.03

0.74

0.0061

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

3 of 19

2.15

1.77

0.00037

KW-0690

Ribosome biogenesis

3 of 21

2.11

1.76

0.00037

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 4

2.65

0.73

0.0482

IPR023179

GTP-binding protein, orthogonal bundle domain superfamily

2 of 4

2.65

0.73

0.0482

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