Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pykAPyruvate kinase II; silverDB:etchr01487; Belongs to the pyruvate kinase family. (493 aa)    
Predicted Functional Partners:
eno
Enolase (2-phospho-D-glycerate hydrolyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
  
 0.976
pgi
Glucose-6-phosphate isomerase (Phosphoglucose isomerase); silverDB:etchr03098; Belongs to the GPI family.
  
 0.951
sfcA
NAD-dependent malic enzyme; silverDB:etchr01285; Belongs to the malic enzymes family.
  
 0.936
pckA
Phosphoenolpyruvate carboxykinase (PEP carboxykinase); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
     
 0.923
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.922
aceE
Pyruvate dehydrogenase, E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.922
ldhA
D-lactate dehydrogenase; silverDB:etchr01649; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 0.922
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.921
tRNA-Val
tRNA-Val; tRNAscan-SE-score 94.20; Belongs to the pyruvate kinase family.
  
  
 
0.914
pflB
Formate acetyltransferase 1; silverDB:etchr02136.
   
 
 0.913
Your Current Organism:
Erwinia tasmaniensis
NCBI taxonomy Id: 465817
Other names: E. tasmaniensis Et1/99, Erwinia tasmaniensis Et1/99, Erwinia tasmaniensis str. Et1/99, Erwinia tasmaniensis strain Et1/99
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