| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | nudE | ETA_01460 | ETA_32130 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | ADP compounds hydrolase NudE; silverDB:etchr03199. | 0.502 |
| birA | prs | ETA_01460 | ETA_18830 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.441 |
| birA | yqiE | ETA_01460 | ETA_04330 | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative resistance protein; silverDB:etchr00433. | 0.502 |
| cueR | nudE | ETA_24540 | ETA_32130 | HTH-type transcriptional regulator CueR (Copper export regulator); silverDB:etchr02442. | ADP compounds hydrolase NudE; silverDB:etchr03199. | 0.532 |
| deoB | nudE | ETA_06680 | ETA_32130 | Phosphopentomutase precursor; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | ADP compounds hydrolase NudE; silverDB:etchr03199. | 0.901 |
| deoB | pgm | ETA_06680 | ETA_23210 | Phosphopentomutase precursor; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Phosphoglucomutase; silverDB:etchr02309. | 0.900 |
| deoB | prs | ETA_06680 | ETA_18830 | Phosphopentomutase precursor; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.914 |
| deoB | yqiE | ETA_06680 | ETA_04330 | Phosphopentomutase precursor; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | Putative resistance protein; silverDB:etchr00433. | 0.901 |
| nudE | birA | ETA_32130 | ETA_01460 | ADP compounds hydrolase NudE; silverDB:etchr03199. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.502 |
| nudE | cueR | ETA_32130 | ETA_24540 | ADP compounds hydrolase NudE; silverDB:etchr03199. | HTH-type transcriptional regulator CueR (Copper export regulator); silverDB:etchr02442. | 0.532 |
| nudE | deoB | ETA_32130 | ETA_06680 | ADP compounds hydrolase NudE; silverDB:etchr03199. | Phosphopentomutase precursor; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | 0.901 |
| nudE | pgm | ETA_32130 | ETA_23210 | ADP compounds hydrolase NudE; silverDB:etchr03199. | Phosphoglucomutase; silverDB:etchr02309. | 0.900 |
| nudE | prs | ETA_32130 | ETA_18830 | ADP compounds hydrolase NudE; silverDB:etchr03199. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.902 |
| nudE | rnr | ETA_32130 | ETA_29600 | ADP compounds hydrolase NudE; silverDB:etchr03199. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily. | 0.415 |
| nudE | yqiE | ETA_32130 | ETA_04330 | ADP compounds hydrolase NudE; silverDB:etchr03199. | Putative resistance protein; silverDB:etchr00433. | 0.900 |
| pgm | deoB | ETA_23210 | ETA_06680 | Phosphoglucomutase; silverDB:etchr02309. | Phosphopentomutase precursor; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. | 0.900 |
| pgm | nudE | ETA_23210 | ETA_32130 | Phosphoglucomutase; silverDB:etchr02309. | ADP compounds hydrolase NudE; silverDB:etchr03199. | 0.900 |
| pgm | prs | ETA_23210 | ETA_18830 | Phosphoglucomutase; silverDB:etchr02309. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.909 |
| pgm | yqiE | ETA_23210 | ETA_04330 | Phosphoglucomutase; silverDB:etchr02309. | Putative resistance protein; silverDB:etchr00433. | 0.904 |
| prs | birA | ETA_18830 | ETA_01460 | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | Bifunctional protein: biotin operon repressor and biotin-[acetyl-CoA carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.441 |