ppnK protein (Legionella maceachernii) - STRING interaction network

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ppnK

Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa)

Predicted Functional Partners:

pnaB

0.942

nadE

0.939

pntA

0.934

recN_1

0.906

nadD

0.900

pntB

0.867

typA

0.694

lpdA

0.565

Lmac_1556

0.565

ribD

0.533

Your Current Organism:

Legionella maceachernii

NCBI taxonomy Id: 466
Other names: ATCC 35300, CCUG 31116, CIP 103846, DSM 16642, JCM 7566, L. maceachernii, NCTC 11982, Tatlockia maceachernii, strain Px-1-G-2-E2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lmac_1556	nadD	Lmac_1556	Lmac_1540	Oxydoreductase.	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.549
Lmac_1556	nadE	Lmac_1556	Lmac_0692	Oxydoreductase.	Glutamine dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.634
Lmac_1556	pnaB	Lmac_1556	Lmac_0902	Oxydoreductase.	NAD(P) transhydrogenase subunit beta.	0.575
Lmac_1556	pntA	Lmac_1556	Lmac_0901	Oxydoreductase.	Pyridine nucleotide transhydrogenase, alpha subunit.	0.602
Lmac_1556	pntB	Lmac_1556	Lmac_0903	Oxydoreductase.	NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	0.597
Lmac_1556	ppnK	Lmac_1556	Lmac_0154	Oxydoreductase.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.565
lpdA	nadD	Lmac_0720	Lmac_1540	Dihydrolipoyl dehydrogenase.	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.549
lpdA	nadE	Lmac_0720	Lmac_0692	Dihydrolipoyl dehydrogenase.	Glutamine dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.634
lpdA	pnaB	Lmac_0720	Lmac_0902	Dihydrolipoyl dehydrogenase.	NAD(P) transhydrogenase subunit beta.	0.575
lpdA	pntA	Lmac_0720	Lmac_0901	Dihydrolipoyl dehydrogenase.	Pyridine nucleotide transhydrogenase, alpha subunit.	0.602
lpdA	pntB	Lmac_0720	Lmac_0903	Dihydrolipoyl dehydrogenase.	NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	0.597
lpdA	ppnK	Lmac_0720	Lmac_0154	Dihydrolipoyl dehydrogenase.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.565
nadD	Lmac_1556	Lmac_1540	Lmac_1556	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Oxydoreductase.	0.549
nadD	lpdA	Lmac_1540	Lmac_0720	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Dihydrolipoyl dehydrogenase.	0.549
nadD	nadE	Lmac_1540	Lmac_0692	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Glutamine dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.970
nadD	pnaB	Lmac_1540	Lmac_0902	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	NAD(P) transhydrogenase subunit beta.	0.858
nadD	pntA	Lmac_1540	Lmac_0901	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Pyridine nucleotide transhydrogenase, alpha subunit.	0.858
nadD	pntB	Lmac_1540	Lmac_0903	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	0.925
nadD	ppnK	Lmac_1540	Lmac_0154	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.900
nadD	ribD	Lmac_1540	Lmac_2194	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	0.694

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