| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Lmac_2148 | Lmac_2711 | Lmac_2148 | Lmac_2711 | Polyketide synthase module. | Polyketide synthase module. | 0.998 |
| Lmac_2148 | bioD | Lmac_2148 | Lmac_2080 | Polyketide synthase module. | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.588 |
| Lmac_2148 | gcvPB | Lmac_2148 | Lmac_3145 | Polyketide synthase module. | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.411 |
| Lmac_2148 | glyA | Lmac_2148 | Lmac_0426 | Polyketide synthase module. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.862 |
| Lmac_2148 | kbl | Lmac_2148 | Lmac_0410 | Polyketide synthase module. | 2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.982 |
| Lmac_2148 | ltaE | Lmac_2148 | Lmac_1062 | Polyketide synthase module. | Low specificity L-threonine aldolase. | 0.615 |
| Lmac_2148 | pksJ | Lmac_2148 | Lmac_2149 | Polyketide synthase module. | Polyketide synthase, type I. | 0.999 |
| Lmac_2148 | tdh | Lmac_2148 | Lmac_0411 | Polyketide synthase module. | Threonine(-3-)dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.414 |
| Lmac_2148 | ydfG | Lmac_2148 | Lmac_2094 | Polyketide synthase module. | NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.905 |
| Lmac_2711 | Lmac_2148 | Lmac_2711 | Lmac_2148 | Polyketide synthase module. | Polyketide synthase module. | 0.998 |
| Lmac_2711 | glyA | Lmac_2711 | Lmac_0426 | Polyketide synthase module. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.494 |
| Lmac_2711 | kbl | Lmac_2711 | Lmac_0410 | Polyketide synthase module. | 2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.865 |
| Lmac_2711 | pksJ | Lmac_2711 | Lmac_2149 | Polyketide synthase module. | Polyketide synthase, type I. | 0.999 |
| Lmac_2711 | ydfG | Lmac_2711 | Lmac_2094 | Polyketide synthase module. | NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.685 |
| bioD | Lmac_2148 | Lmac_2080 | Lmac_2148 | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Polyketide synthase module. | 0.588 |
| bioD | kbl | Lmac_2080 | Lmac_0410 | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.860 |
| gcsA | gcvPB | Lmac_3143 | Lmac_3145 | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
| gcsA | glyA | Lmac_3143 | Lmac_0426 | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.932 |
| gcsA | kbl | Lmac_3143 | Lmac_0410 | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.868 |
| gcsA | ltaE | Lmac_3143 | Lmac_1062 | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | Low specificity L-threonine aldolase. | 0.881 |
