xapA_2 protein (Legionella maceachernii) - STRING interaction network

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xapA_2

Xanthosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (292 aa)

Predicted Functional Partners:

apt

0.984

mtnA

0.938

fucA

0.891

Lmac_1028

0.819

ppt

0.685

add_1

0.617

add_2

0.617

surE

0.605

deoB

0.601

Lmac_1267

0.601

Your Current Organism:

Legionella maceachernii

NCBI taxonomy Id: 466
Other names: ATCC 35300, CCUG 31116, CIP 103846, DSM 16642, JCM 7566, L. maceachernii, NCTC 11982, Tatlockia maceachernii, strain Px-1-G-2-E2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lmac_1028	apt	Lmac_1028	Lmac_1025	Coproporphyrinogen III oxidase.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.773
Lmac_1028	fucA	Lmac_1028	Lmac_1026	Coproporphyrinogen III oxidase.	L-fuculose phosphate aldolase.	0.773
Lmac_1028	mtnA	Lmac_1028	Lmac_1024	Coproporphyrinogen III oxidase.	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).	0.724
Lmac_1028	xapA_2	Lmac_1028	Lmac_1027	Coproporphyrinogen III oxidase.	Xanthosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.	0.819
Lmac_1267	surE	Lmac_1267	Lmac_2541	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.858
Lmac_1267	xapA_2	Lmac_1267	Lmac_1027	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	Xanthosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.	0.601
add_1	add_2	Lmac_1952	Lmac_2870	Adenosine deaminase.	Adenosine deaminase.	0.891
add_1	apt	Lmac_1952	Lmac_1025	Adenosine deaminase.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.759
add_1	ppt	Lmac_1952	Lmac_1526	Adenosine deaminase.	Hypoxanthine-guanine phosphoribosyltransferase.	0.819
add_1	surE	Lmac_1952	Lmac_2541	Adenosine deaminase.	Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.863
add_1	xapA_2	Lmac_1952	Lmac_1027	Adenosine deaminase.	Xanthosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.	0.617
add_2	add_1	Lmac_2870	Lmac_1952	Adenosine deaminase.	Adenosine deaminase.	0.891
add_2	apt	Lmac_2870	Lmac_1025	Adenosine deaminase.	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	0.759
add_2	ppt	Lmac_2870	Lmac_1526	Adenosine deaminase.	Hypoxanthine-guanine phosphoribosyltransferase.	0.595
add_2	surE	Lmac_2870	Lmac_2541	Adenosine deaminase.	Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.863
add_2	xapA_2	Lmac_2870	Lmac_1027	Adenosine deaminase.	Xanthosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.	0.617
apt	Lmac_1028	Lmac_1025	Lmac_1028	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Coproporphyrinogen III oxidase.	0.773
apt	add_1	Lmac_1025	Lmac_1952	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Adenosine deaminase.	0.759
apt	add_2	Lmac_1025	Lmac_2870	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	Adenosine deaminase.	0.759
apt	fucA	Lmac_1025	Lmac_1026	Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.	L-fuculose phosphate aldolase.	0.823

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