Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mvaAHydroxymethylglutaryl CoA reductase; Belongs to the HMG-CoA reductase family. (432 aa)    
Predicted Functional Partners:
Lmac_1962
Putative mevalonate kinase.
 
 0.978
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.975
Lmac_1973
Hypothetical protein.
  
 0.928
Lmac_1963
Mevalonate diphosphate decarboxylase.
 
 
 0.914
Lmac_1969
ABC transporter ATP binding protein.
       0.675
Lmac_1967
Transport protein.
       0.501
Lmac_1968
ABC transport system periplasmic substrate binding protein.
       0.501
ispA
Geranyltranstransferase; Belongs to the FPP/GGPP synthase family.
  
 
 0.461
ispB
Octaprenyl diphosphate synthase IspB; Belongs to the FPP/GGPP synthase family.
  
 
 0.461
Lmac_1970
ABC transporter permease.
       0.449
Your Current Organism:
Legionella maceachernii
NCBI taxonomy Id: 466
Other names: ATCC 35300, CCUG 31116, CIP 103846, DSM 16642, JCM 7566, L. maceachernii, NCTC 11982, Tatlockia maceachernii, strain Px-1-G-2-E2
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.