Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
gcaGDP-mannose 4,6-dehydratase. (343 aa)    
Predicted Functional Partners:
fcl
Bifunctional GDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
 
  0.891
cpsB_2
Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family.
  
 
 0.848
cpsB_1
Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family.
  
 
 0.739
Lmac_0587
Capsular polysaccharide biosynthesis protein CapD and UDP-glucose 4-epimerase.
  
  
 0.709
gmd
GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
  
  
 
0.622
Lmac_3037
Hypothetical protein.
 
 
 0.589
Lmac_3038
Glycosyl transferase group 1.
 
 
 0.526
Lmac_2897
Chloramphenicol acetyltransferase.
  
 
 0.480
Lmac_3031
NAD-dependent epimerase/dehydratase.
  
  0.477
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
    
   0.458
Your Current Organism:
Legionella maceachernii
NCBI taxonomy Id: 466
Other names: ATCC 35300, CCUG 31116, CIP 103846, DSM 16642, JCM 7566, L. maceachernii, NCTC 11982, Tatlockia maceachernii, strain Px-1-G-2-E2
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