| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMB84897.1 | AMB84994.1 | AWM79_06070 | AWM79_06585 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.873 |
| AMB84897.1 | AMB87322.1 | AWM79_06070 | AWM79_19290 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-3B C(17)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.981 |
| AMB84897.1 | AMB87323.1 | AWM79_06070 | AWM79_19300 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-8X methylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.937 |
| AMB84897.1 | AMB87325.1 | AWM79_06070 | AWM79_19310 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-6Y C5,15-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.950 |
| AMB84897.1 | AMB87327.1 | AWM79_06070 | AWM79_19320 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | cobalt-precorrin-6A reductase; CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.875 |
| AMB84897.1 | AMB88234.1 | AWM79_06070 | AWM79_06065 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-4 C(11)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
| AMB84897.1 | AMB88354.1 | AWM79_06070 | AWM79_19295 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.926 |
| AMB84897.1 | cbiD | AWM79_06070 | AWM79_19315 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | cobalt-precorrin-5B (C(1))-methyltransferase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.984 |
| AMB84897.1 | cobQ | AWM79_06070 | AWM79_11530 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.705 |
| AMB84897.1 | cysG | AWM79_06070 | AWM79_14410 | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.892 |
| AMB84994.1 | AMB84897.1 | AWM79_06585 | AWM79_06070 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.873 |
| AMB84994.1 | AMB87322.1 | AWM79_06585 | AWM79_19290 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-3B C(17)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.994 |
| AMB84994.1 | AMB87323.1 | AWM79_06585 | AWM79_19300 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-8X methylmutase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.977 |
| AMB84994.1 | AMB87325.1 | AWM79_06585 | AWM79_19310 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | precorrin-6Y C5,15-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.970 |
| AMB84994.1 | AMB87327.1 | AWM79_06585 | AWM79_19320 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | cobalt-precorrin-6A reductase; CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.986 |
| AMB84994.1 | AMB88234.1 | AWM79_06585 | AWM79_06065 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-4 C(11)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.982 |
| AMB84994.1 | AMB88354.1 | AWM79_06585 | AWM79_19295 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | Precorrin-2 C(20)-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.751 |
| AMB84994.1 | cbiD | AWM79_06585 | AWM79_19315 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | cobalt-precorrin-5B (C(1))-methyltransferase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.676 |
| AMB84994.1 | cobQ | AWM79_06585 | AWM79_11530 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.868 |
| AMB84994.1 | cysG | AWM79_06585 | AWM79_14410 | Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.861 |
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