node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEG18_00680 | CEG18_00765 | GCA_000807755_03386 | GCA_000807755_06136 | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Unannotated protein; Belongs to the ALAD family. | 0.979 |
CEG18_00680 | cobA | GCA_000807755_03386 | GCA_000807755_01389 | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Unannotated protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.949 |
CEG18_00680 | hemC | GCA_000807755_03386 | GCA_000807755_03387 | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Unannotated protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
CEG18_00680 | hemE | GCA_000807755_03386 | GCA_000807755_04716 | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Unannotated protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.813 |
CEG18_00680 | hemF | GCA_000807755_03386 | GCA_000807755_05940 | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Unannotated protein; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.427 |
CEG18_00680 | hemH | GCA_000807755_03386 | GCA_000807755_00877 | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Unannotated protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.480 |
CEG18_00765 | CEG18_00680 | GCA_000807755_06136 | GCA_000807755_03386 | Unannotated protein; Belongs to the ALAD family. | Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.979 |
CEG18_00765 | cobA | GCA_000807755_06136 | GCA_000807755_01389 | Unannotated protein; Belongs to the ALAD family. | Unannotated protein; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.979 |
CEG18_00765 | hemC | GCA_000807755_06136 | GCA_000807755_03387 | Unannotated protein; Belongs to the ALAD family. | Unannotated protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
CEG18_00765 | hemE | GCA_000807755_06136 | GCA_000807755_04716 | Unannotated protein; Belongs to the ALAD family. | Unannotated protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.798 |
CEG18_00765 | hemF | GCA_000807755_06136 | GCA_000807755_05940 | Unannotated protein; Belongs to the ALAD family. | Unannotated protein; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.572 |
CEG18_00765 | hemH | GCA_000807755_06136 | GCA_000807755_00877 | Unannotated protein; Belongs to the ALAD family. | Unannotated protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.587 |
CEG18_00765 | hemN | GCA_000807755_06136 | GCA_000807755_01751 | Unannotated protein; Belongs to the ALAD family. | Unannotated protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.448 |
CEG18_00765 | hemN-2 | GCA_000807755_06136 | GCA_000807755_06595 | Unannotated protein; Belongs to the ALAD family. | Unannotated protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.446 |
CEG18_01205 | CEG18_02130 | GCA_000807755_06226 | GCA_000807755_04714 | Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Unannotated protein. | 0.500 |
CEG18_01205 | hemE | GCA_000807755_06226 | GCA_000807755_04716 | Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Unannotated protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.817 |
CEG18_01205 | hemF | GCA_000807755_06226 | GCA_000807755_05940 | Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Unannotated protein; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.777 |
CEG18_01205 | hemN | GCA_000807755_06226 | GCA_000807755_01751 | Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Unannotated protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.659 |
CEG18_01205 | hemN-2 | GCA_000807755_06226 | GCA_000807755_06595 | Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Unannotated protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.650 |
CEG18_02130 | CEG18_01205 | GCA_000807755_04714 | GCA_000807755_06226 | Unannotated protein. | Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.500 |