EFL37374.1 protein (Streptomyces griseoflavus)

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[Homology]

Score

EFL37374.1

DNA-binding protein. (215 aa)

Predicted Functional Partners:

EFL42248.1

0.749

EFL37290.1

0.698

thyA

0.698

clpX

0.653

clpP

0.536

clpP-2

0.536

clpP-3

0.536

clpP-4

0.536

clpP-5

0.536

EFL37373.1

0.502

Your Current Organism:

Streptomyces griseoflavus

NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFL37290.1	EFL37374.1	SSRG_00094	SSRG_00178	Thymidylate synthase.	DNA-binding protein.	0.698
EFL37290.1	EFL42248.1	SSRG_00094	SSRG_05052	Thymidylate synthase.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.620
EFL37373.1	EFL37374.1	SSRG_00177	SSRG_00178	Monooxygenase.	DNA-binding protein.	0.502
EFL37374.1	EFL37290.1	SSRG_00178	SSRG_00094	DNA-binding protein.	Thymidylate synthase.	0.698
EFL37374.1	EFL37373.1	SSRG_00178	SSRG_00177	DNA-binding protein.	Monooxygenase.	0.502
EFL37374.1	EFL42248.1	SSRG_00178	SSRG_05052	DNA-binding protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.749
EFL37374.1	clpP	SSRG_00178	SSRG_00481	DNA-binding protein.	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.536
EFL37374.1	clpP-2	SSRG_00178	SSRG_00482	DNA-binding protein.	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.536
EFL37374.1	clpP-3	SSRG_00178	SSRG_04165	DNA-binding protein.	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.536
EFL37374.1	clpP-4	SSRG_00178	SSRG_04166	DNA-binding protein.	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.536
EFL37374.1	clpP-5	SSRG_00178	SSRG_05431	DNA-binding protein.	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.536
EFL37374.1	clpX	SSRG_00178	SSRG_04167	DNA-binding protein.	ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.	0.653
EFL37374.1	thyA	SSRG_00178	SSRG_00265	DNA-binding protein.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.698
EFL42248.1	EFL37290.1	SSRG_05052	SSRG_00094	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Thymidylate synthase.	0.620
EFL42248.1	EFL37374.1	SSRG_05052	SSRG_00178	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	DNA-binding protein.	0.749
EFL42248.1	thyA	SSRG_05052	SSRG_00265	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.620
clpP	EFL37374.1	SSRG_00481	SSRG_00178	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	DNA-binding protein.	0.536
clpP	clpP-2	SSRG_00481	SSRG_00482	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.994
clpP	clpP-3	SSRG_00481	SSRG_04165	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.562
clpP	clpP-4	SSRG_00481	SSRG_04166	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.958

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