| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFL37290.1 | EFL37462.1 | SSRG_00094 | SSRG_00266 | Thymidylate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.994 |
| EFL37290.1 | EFL41367.1 | SSRG_00094 | SSRG_04171 | Thymidylate synthase. | Tetrahydrofolate synthase. | 0.889 |
| EFL37290.1 | EFL42248.1 | SSRG_00094 | SSRG_05052 | Thymidylate synthase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.668 |
| EFL37290.1 | fmt | SSRG_00094 | SSRG_05265 | Thymidylate synthase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.856 |
| EFL37290.1 | gcvT | SSRG_00094 | SSRG_01773 | Thymidylate synthase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.914 |
| EFL37290.1 | glyA | SSRG_00094 | SSRG_01775 | Thymidylate synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.784 |
| EFL37290.1 | purH | SSRG_00094 | SSRG_02398 | Thymidylate synthase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.655 |
| EFL37290.1 | purN | SSRG_00094 | SSRG_02399 | Thymidylate synthase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.576 |
| EFL37462.1 | EFL37290.1 | SSRG_00266 | SSRG_00094 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase. | 0.994 |
| EFL37462.1 | EFL41367.1 | SSRG_00266 | SSRG_04171 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Tetrahydrofolate synthase. | 0.977 |
| EFL37462.1 | EFL42248.1 | SSRG_00266 | SSRG_05052 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.905 |
| EFL37462.1 | fmt | SSRG_00266 | SSRG_05265 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.938 |
| EFL37462.1 | gcvT | SSRG_00266 | SSRG_01773 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.948 |
| EFL37462.1 | glyA | SSRG_00266 | SSRG_01775 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.744 |
| EFL37462.1 | purH | SSRG_00266 | SSRG_02398 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.902 |
| EFL37462.1 | purN | SSRG_00266 | SSRG_02399 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.905 |
| EFL37462.1 | purU | SSRG_00266 | SSRG_03592 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.899 |
| EFL37462.1 | thyA | SSRG_00266 | SSRG_00265 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| EFL41367.1 | EFL37290.1 | SSRG_04171 | SSRG_00094 | Tetrahydrofolate synthase. | Thymidylate synthase. | 0.889 |
| EFL41367.1 | EFL37462.1 | SSRG_04171 | SSRG_00266 | Tetrahydrofolate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.977 |
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