Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EFL37921.1Type II restriction enzyme, methylase subunit. (99 aa)    
Predicted Functional Partners:
EFL41895.1
Glutamate synthase large subunit.
  
    0.733
EFL40981.1
Cystathionine beta-synthase.
    
  0.732
pheT
phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
    
  0.533
EFL41815.1
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
    
  0.507
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
     
  0.489
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.
     
  0.489
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
     
  0.489
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
     
  0.489
EFL42248.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
  0.481
EFL37922.1
Serine/arginine repetitive matrix protein 2.
       0.456
Your Current Organism:
Streptomyces griseoflavus
NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000
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